Pawate Siddharama, Sriram Subramaniam
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Ann Indian Acad Neurol. 2010 Apr;13(2):80-6. doi: 10.4103/0972-2327.64622.
Interplay between susceptibility genes and environmental factors is considered important player in the genesis of multiple sclerosis (MS). Among environmental factors, a role for an infectious pathogen has long been considered central to the disease process. This opinion has support both from epidemiological data and the findings of immunological abnormalities in spinal fluid that reflect an immune response to an as yet undetermined antigen, possibly a pathogen, in the cerebrospinal fluid. Our review will outline the current understanding of the role of infection in the causation and progression of MS. We will review the data that point to an infectious cause of MS and consider the specific agents Chlamydophila (Chlamydia) pneumoniae, Human Herpes Virus 6, and Epstein-Barr Virus, that are implicated in either the development or progression of MS.
易感性基因与环境因素之间的相互作用被认为是多发性硬化症（MS）发病机制中的重要因素。在环境因素中，感染性病原体长期以来一直被视为该疾病进程的核心因素。这一观点得到了流行病学数据以及脑脊液中免疫异常结果的支持，这些免疫异常反映了对脑脊液中一种尚未确定的抗原（可能是病原体）的免疫反应。我们的综述将概述目前对感染在MS病因和进展中作用的理解。我们将回顾指向MS感染病因的数据，并考虑与MS发生或进展相关的特定病原体，即肺炎衣原体、人类疱疹病毒6型和爱泼斯坦-巴尔病毒。
