Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing, PR China.
Drug Dev Ind Pharm. 2010 Oct;36(10):1235-44. doi: 10.3109/03639041003710151.
Investigated the self-assembly and characterization of novel antifouling polyethylene glycol (PEG)-coated iron oxide nanoparticles as nanoprobes for magnetic resonance imaging (MRI) contrast agent.
Monodisperse oleic acid-coated superparamagnetic iron oxide cores are synthesized by thermal decomposition of iron oleate. The self-assembly behavior between iron oxide cores and PEG-lipid conjugates in water and their characteristics are confirmed by transmission electron microscope, X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, and vibrating sample magnetometer.
Dynamic light scattering shows superparamagnetic iron oxide nanoparticles coated with PEG are stable in water for pH of 3-10 and ionic strengths up to 0.3 M NaCl, and are protein resistant in physiological conditions. Additionally, in vitro MRI study demonstrates the efficient magnetic resonance imaging contrast characteristics of the iron oxide nanoparticles.
The result indicates that the novel antifouling PEG-coated superparamagnetic iron oxide nanoparticles could potentially be used in a wide range of applications such as biotechnology, MRI, and magnetic fluid hyperthermia.
研究新型抗污聚乙二醇（PEG）涂层氧化铁纳米粒子的自组装和特性，将其作为磁共振成像（MRI）造影剂的纳米探针。
通过油酸铁热分解合成单分散油酸酯包覆的超顺磁性氧化铁核。通过透射电子显微镜、X 射线衍射、热重分析、傅里叶变换红外光谱和振动样品磁强计确认氧化铁核与 PEG-脂质缀合物在水中的自组装行为及其特性。
动态光散射表明，在 pH 值为 3-10 和离子强度高达 0.3 M NaCl 的条件下，PEG 包覆的超顺磁性氧化铁纳米粒子在水中稳定，并且在生理条件下具有抗蛋白质特性。此外，体外 MRI 研究表明氧化铁纳米粒子具有高效的磁共振成像对比特性。
结果表明，新型抗污 PEG 涂层超顺磁性氧化铁纳米粒子可能在生物技术、MRI 和磁性流体热疗等广泛应用中得到应用。
