Wu Yanyue, Lu Zhiguo, Li Yan, Yang Jun, Zhang Xin
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
Nanomaterials (Basel). 2020 Jul 24;10(8):1441. doi: 10.3390/nano10081441.
Combining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coatings, polymers coatings, lipid coatings and lipopolymer coatings. These surface modifications facilitate iron nanoparticles to cross the blood-brain-barrier, which is essential for diagnosis and treatments of brain diseases. Here we focus on the characteristics of different coated INOPs and their application in brain disease, particularly gliomas, Alzheimer's disease (AD) and Parkinson's disease (PD). Moreover, we summarize the current progress and expect to provide help for future researches.
将诊断与治疗相结合，磁性氧化铁纳米颗粒（INOPs）作为药物递送的重要载体。然而，INOPs较差的生物相容性限制了它们的应用。为了改善这些缺点，人们开发了各种表面修饰方法，包括小分子涂层、聚合物涂层、脂质涂层和脂质聚合物涂层。这些表面修饰有助于铁纳米颗粒穿过血脑屏障，这对于脑部疾病的诊断和治疗至关重要。在此，我们重点关注不同涂层的INOPs的特性及其在脑部疾病，特别是神经胶质瘤、阿尔茨海默病（AD）和帕金森病（PD）中的应用。此外，我们总结了当前的进展，并期望为未来的研究提供帮助。
