Ma Lina, Chan Piu
1Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
2China National Clinical Research Center for Geriatric Medicine, Beijing, China.
Aging Dis. 2020 Mar 9;11(2):405-418. doi: 10.14336/AD.2019.0521. eCollection 2020 Apr.
Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical frailty to cognitive decline, a complete understanding of the underpinning biological basis of the two disorders remains fragmented. This narrative review discusses insights into the potential roles of chronic inflammation, impaired hypothalamic-pituitary axis stress response, imbalanced energy metabolism, mitochondrial dysfunction, oxidative stress, and neuroendocrine dysfunction linking physical frailty with cognitive decline. We highlight the importance of easier identification of strategic approaches delaying the progression and onset of physical frailty and cognitive decline as well as preventing disability in the older population.
身体和认知功能的衰退都与年龄增长相关。了解身体虚弱与认知衰退之间的生理联系，可能使我们能够开发出预防和治疗这两种情况的干预措施。尽管有大量流行病学证据表明身体虚弱与认知衰退有关，但对这两种疾病潜在生物学基础的全面理解仍然支离破碎。这篇叙述性综述讨论了关于慢性炎症、下丘脑 - 垂体轴应激反应受损、能量代谢失衡、线粒体功能障碍、氧化应激以及神经内分泌功能障碍在身体虚弱与认知衰退之间潜在作用的见解。我们强调了更易于识别战略方法以延缓身体虚弱和认知衰退的进展及发病，并预防老年人群残疾的重要性。
