Dr. Lina Ma, Department of Geriatrics, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China. E-mail:
J Nutr Health Aging. 2019;23(3):246-250. doi: 10.1007/s12603-018-1149-7.
Because frailty is a major health concern among older patients, identifying frailty-related biomarkers will help in the early detection and prevention of frailty. Thus, we aimed to determine the association between circulating levels of silent mating-type information regulation 2 homolog 1 (SIRT1) and frailty.
We assessed circulating SIRT1 levels in 16 robust, 74 prefrail, and 40 frail older adults. Frailty was diagnosed based on the Fried phenotype. Circulating cytokine and adipokine (e.g., vaspin, adiponectin, and leptin) levels were assessed. Differences in SIRT1 levels among the three subject groups were compared; correlations of SIRT1 levels with physical function and adipokine and cytokine levels were analyzed.
Serum SIRT1 levels were significantly higher among frail older adults than among robust ones. Older adults with slowness or weight loss had high SIRT1 levels. Serum SIRT1 levels negatively correlated with gait speed, even after adjustment for age and sex; age; and insulin, vaspin, and leptin levels; they correlated negatively with phospholipase A2 levels.
High SIRT1 levels were observed in frail elderly patients and were correlated with decreased physical function. Insulin and adipokine levels might be the link between SIRT1 and frailty, whereas inflammation may not be involved in this process.
由于虚弱是老年患者的主要健康问题，因此识别与虚弱相关的生物标志物将有助于早期发现和预防虚弱。因此，我们旨在确定循环沉默交配型信息调节 2 同源物 1（SIRT1）水平与虚弱之间的关联。
我们评估了 16 名健康、74 名虚弱前期和 40 名虚弱老年人的循环 SIRT1 水平。根据 Fried 表型诊断虚弱。评估循环细胞因子和脂肪因子（如 vaspin、脂联素和瘦素）水平。比较三组受试者之间 SIRT1 水平的差异；分析 SIRT1 水平与身体功能以及脂肪因子和细胞因子水平的相关性。
与健康老年人相比，虚弱老年人的血清 SIRT1 水平明显更高。动作缓慢或体重减轻的老年人 SIRT1 水平较高。血清 SIRT1 水平与步态速度呈负相关，即使在调整年龄、性别、年龄、胰岛素、vaspin 和瘦素水平后也是如此；它们与磷酸酶 A2 水平呈负相关。
虚弱的老年患者中观察到高水平的 SIRT1，与身体功能下降有关。胰岛素和脂肪因子水平可能是 SIRT1 与虚弱之间的联系，而炎症可能不参与这一过程。
