Abbott Bioresearch Center, Worcester, MA 01545, USA.
Curr Osteoporos Rep. 2010 Dec;8(4):235-40. doi: 10.1007/s11914-010-0035-y.
In recent decades the population of both elderly men and women has grown substantially worldwide. Aging is associated with a number of pathologies involving various organs including the skeleton. Age-related bone loss and resultant osteoporosis put the elderly population at an increased risk for fractures and morbidity. Fortunately, in parallel our understanding of this malady has also grown substantially in recent years. A number of clinical as well as translational studies have been pivotal in providing us with an understanding of the pathophysiology of this condition. This article discusses the current concepts of age-related modulation of the skeleton involving intrinsic factors such as genetics, hormonal changes, levels of oxidative stress, and changes in telomere length, as well as extrinsic factors such as nutritional and lifestyle choices. It also briefly outlines recent studies on the relationship between bone and fat in the marrow as well as the periphery.
近几十年来，全世界老年男性和女性的人口数量都大幅增长。衰老与许多涉及包括骨骼在内的各种器官的疾病有关。与年龄相关的骨丢失和由此导致的骨质疏松症使老年人群骨折和发病的风险增加。幸运的是，近年来我们对这种疾病的理解也有了很大的提高。一些临床和转化研究对我们理解这种疾病的病理生理学起着关键作用。本文讨论了与内在因素（如遗传、激素变化、氧化应激水平和端粒长度的变化）以及外在因素（如营养和生活方式的选择）相关的骨骼与年龄相关的调节的当前概念。它还简要概述了最近关于骨髓和外周骨与脂肪之间关系的研究。
