[Effect of disconnection of various types of autonomic mediation on the adenyl system of the cortex of a solitary kidney].

The authors studied the ATP, ADP, and AMP intratissue content and the energy charge of the kidney cortex in compensatory hypertrophy during a continuous blocking effect produced by daily guanethidine and atropine injections on the transsynaptic mechanisms of sympathetic and parasympathetic neuromediation. Chronic disorders of energy metabolism were noted in both groups, which were more marked in deparasympathization. Complex combinations of the constant functional load exerted on the organ with the metabolic effects of the mediatory block in the tissues and disorders of their blood supply are the causes of tissue energy deficiency. The disorders of energy metabolism in the late periods of the experiment (after 60 days) in both cases were caused by deterioration of the blood supply to the cortex due, probably, to the noted accumulation in the tissue of metabolites of macroergic compounds which are vasoconstrictors of the renal arterioles.