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[慢性去神经支配后孤立肾皮质中腺嘌呤核苷酸池及谱的变化]

[Changes in the pool and spectrum of adenine nucleotides in the cortex of the solitary kidney in chronic denervation].

作者信息

Barinov E F, Kot A G, Iakubenko E D

出版信息

Fiziol Zh (1978). 1989 Sep-Oct;35(5):23-30.

PMID:2591578
Abstract

Chronic energy-++-deficient condition of nephron cortical portions manifested in a two ware pool decrease and spectrum impairment of the adenyl system components was revealed as a result of the long-term studies in tissue contents of ATP, ADP, AMP in the rat renal cortex under conditions of experimental combination of compensatory hypertrophy and chronic nervous decentralization. A negative trophic effect of chronically overloaded cortex tissue de-mediation is responsible for energy metabolism at the early phase while at the later stage, beginning two months after the experiment, the progressing hypoperfusion of the cortical tubular system of a single denervated kidney is.

摘要

通过对大鼠肾皮质中ATP、ADP、AMP组织含量进行长期研究,在代偿性肥大与慢性神经去传入实验组合条件下,发现肾单位皮质部分的慢性能量缺乏状况表现为腺苷系统成分的双池减少和频谱损伤。在早期,皮质组织去传入长期过载的负性营养作用负责能量代谢,而在后期,即实验开始两个月后,单肾去神经支配的皮质肾小管系统的进行性灌注不足起主要作用。

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