El-Gindy Alaa, Sallam Shehab, Abdel-Salam Randa A
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
J Chromatogr Sci. 2010 Jul;48(6):507-12. doi: 10.1093/chromsci/48.6.507.
A liquid chromatographic method was applied for the analysis of two sustained-release mixtures containing dextromethorphane hydrobromide, carbinoxamine maleate with either phenylephrine hydrochloride in pharmaceutical capsules (Mix 1) or phenyl-propanolamine, methylparaben, and propylparaben, which bonds as a drug base to ion exchange resin in pharmaceutical syrup (Mix 2). The method was used for their simultaneous determination using a CN column with a mobile phase consisting of acetonitrile-12 mM ammonium acetate in the ratio of 60:40 (v/v, pH 6.0) for Mix 1 and 45:55 (v/v, pH 6.0) for Mix 2.
采用液相色谱法分析两种缓释混合物，其中一种含有氢溴酸右美沙芬、马来酸氯苯那敏以及盐酸去氧肾上腺素，制成药用胶囊（混合物1）；另一种含有苯丙醇胺、对羟基苯甲酸甲酯和对羟基苯甲酸丙酯，作为药物基质与药用糖浆中的离子交换树脂结合（混合物2）。该方法用于同时测定这两种混合物，使用氰基柱，流动相为乙腈-12 mM醋酸铵，混合物1中二者比例为60:40（v/v，pH 6.0），混合物2中比例为45:55（v/v，pH 6.0）。
