Department of Radiation Oncology, The Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA.
G Ital Dermatol Venereol. 2010 Aug;145(4):491-507.
The combination of lesion ablation with excellence in cosmetic outcome has allowed photodynamic therapy (PDT) an ever increasing role in the treatment of diseases of the skin. As currently practiced, PDT employs a photosensitizing agent that when activated by light energy creates a photodynamic reaction that is cytotoxic and vasculotoxic. The relative simplicity of therapy with its ability to achieve high response rates has brought PDT to a worldwide audience not only for oncologic indications but far more commonly to non oncologic indications. This paper will review the mechanism of action for PDT and highlight the versatile clinical outcomes reported from the peer reviewed literature.
光动力疗法（PDT）将病变消融与出色的美容效果相结合，使其在皮肤疾病的治疗中发挥着越来越重要的作用。目前，PDT 采用光敏剂，当光敏剂被光能激活时，会产生一种细胞毒性和血管毒性的光动力反应。该疗法相对简单，且能达到高反应率，这使得 PDT 不仅在肿瘤学适应证中，而且在更常见的非肿瘤学适应证中，受到了全球范围内的关注。本文将综述 PDT 的作用机制，并重点介绍同行评议文献中报道的多样化临床疗效。
