Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Int J Cancer. 2011 Jul 1;129(1):180-91. doi: 10.1002/ijc.25653. Epub 2010 Nov 16.
Colorectal cancer mortality has been declining over the last two decades in Europe, particularly in women, the trends being, however, different across countries and age groups. We updated to 2007 colorectal cancer mortality trends in Europe using data from the World Health Organization (WHO). Rates were analyzed for the overall population and separately in young, middle-age and elderly populations. In the European Union (EU), between 1997 and 2007 mortality from colorectal cancer declined by around 2% per year, from 19.7 to 17.4/100,000 men (world standardized rates) and from 12.5 to 10.5/100,000 women. Persisting favorable trends were observed in countries of western and northern Europe, while there were more recent declines in several countries of eastern Europe, including the Czech Republic, Hungary and Slovakia particularly in women (but not Romania and the Russian Federation). In 2007, a substantial excess in colorectal cancer mortality was still observed in Slovakia, Hungary, Croatia, the Czech Republic and Slovenia in men (rates over 25/100,000), and in Hungary, Norway, Denmark and Slovakia in women (rates over 14/100,000). Colorectal mortality trends were more favorable in the young (30-49 years) from most European countries, with a decline of ∼2% per year since the early 1990s in both men and women from the EU. The recent decreases in colorectal mortality rates in several European countries are likely due to improvements in (early) diagnosis and treatment, with a consequent higher survival from the disease. Interventions to further reduce colorectal cancer burden are, however, still warranted, particularly in eastern European countries.
在过去的二十年中，欧洲的结直肠癌死亡率一直在下降，尤其是在女性中，尽管各国和各年龄组的趋势有所不同。我们使用世界卫生组织（WHO）的数据更新了 2007 年欧洲结直肠癌死亡率趋势。对整个人群以及年轻人、中年人和老年人分别进行了分析。在欧盟（EU），1997 年至 2007 年间，男性结直肠癌死亡率每年下降约 2%，从 19.7 降至 17.4/100,000（世界标准化率），女性死亡率从 12.5 降至 10.5/100,000。在西欧和北欧国家，仍观察到持续的有利趋势，而东欧的几个国家，包括捷克共和国、匈牙利和斯洛伐克，最近的死亡率有所下降，尤其是女性（但罗马尼亚和俄罗斯联邦除外）。2007 年，男性结直肠癌死亡率仍明显高于斯洛伐克、匈牙利、克罗地亚、捷克共和国和斯洛文尼亚（死亡率超过 25/100,000），女性死亡率仍明显高于匈牙利、挪威、丹麦和斯洛伐克（死亡率超过 14/100,000）。来自大多数欧洲国家的年轻人（30-49 岁）的结直肠死亡率趋势更为有利，自 20 世纪 90 年代初以来，男性和女性的死亡率每年下降约 2%。几个欧洲国家最近结直肠癌死亡率的下降可能是由于（早期）诊断和治疗的改善，从而提高了对该病的生存率。然而，仍需要采取干预措施来进一步降低结直肠癌的负担，特别是在东欧国家。
