Koo Yean Kyoung, Kim Jeong Mi, Koo Ja Yong, Kang Sam Sik, Bae KiHwan, Kim Yeong Shik, Chung Jin-Ho, Yun-Choi Hye Sook
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Korea.
Pharmazie. 2010 Aug;65(8):624-8.
The roots of two Paeoniaceae family members have long been used as traditional medicines in Korea, China, and Japan. Dry roots of Paeonia lactiflora and dry root bark of P. suffruticosa are used under the traditional names of Paeoniae Radix and Moutan Cortex, respectively. Both Paeoniae Radix and Moutan Cortex have been used as remedies for cardiovascular diseases, for improving blood circulation, or for other uses. It was postulated that both plants may contain common active constituents that contribute to inhibiting blood coagulation and/or platelet aggregation. Eighteen compounds, which have been reported to be present in both plant medicines, were evaluated for their effects on platelet aggregation and blood coagulation. Paeonol (5), paeoniflorin (9), benzoylpaeoniflorin (11), and benzoyloxypaeoniflorin (12) were found to be the major common active constituents and they would collectively contribute to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation. In addition, methylgallate (4), (+)-catechin (7), paeoniflorigenone (8), galloylpaeoniflorin (13), and daucosterol (16) may also take part in improving blood circulation by inhibiting ether platelet aggregation and/or blood coagulation.
芍药科两个成员的根在韩国、中国和日本长期以来一直被用作传统药物。芍药的干燥根和牡丹的干燥根皮分别以芍药根和牡丹皮的传统名称使用。芍药根和牡丹皮都被用作心血管疾病的治疗药物、改善血液循环或用于其他用途。据推测，这两种植物可能含有共同的活性成分，有助于抑制血液凝固和/或血小板聚集。对已报道存在于这两种植物药中的18种化合物进行了血小板聚集和血液凝固作用的评估。发现丹皮酚（5）、芍药苷（9）、苯甲酰芍药苷（11）和苯甲酰氧基芍药苷（12）是主要的共同活性成分，它们通过对血小板聚集和血液凝固的抑制作用共同有助于改善血液循环。此外，没食子酸甲酯（4）、（+）-儿茶素（7）、芍药苷元（8）、没食子酰芍药苷（13）和胡萝卜苷（16）也可能通过抑制血小板聚集和/或血液凝固参与改善血液循环。
