Division for Radiation Safety and Immune Tolerance, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan.
Int Immunopharmacol. 2011 Mar;11(3):323-30. doi: 10.1016/j.intimp.2010.08.013. Epub 2010 Sep 8.
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS). It is associated with a variety of pathophysiological features, including breakdown of the blood-brain barrier (BBB), autoimmune attack, injury of axons and myelin sheaths. Th17 cells are considered as a key immunological player for the pathophysiological process of MS. Neuroprotective approaches work best prior to the initiation of damage, suggesting that some safe and effective prophylaxis would be highly desirable. Curcumin, a dietary spice from turmeric, has outstanding anti-inflammation and neuroprotective effects. Herein, we review key features of curcumin involved biology, pharmacology, and medicinal chemistry and discuss its potential relevance to pathophysiological progress of MS.
多发性硬化症（MS）是一种中枢神经系统（CNS）的慢性炎症性自身免疫性疾病。它与多种病理生理特征有关，包括血脑屏障（BBB）的破坏、自身免疫攻击、轴突和髓鞘的损伤。Th17 细胞被认为是 MS 病理生理过程的关键免疫参与者。神经保护方法在损伤发生之前效果最佳，这表明需要高度理想的一些安全有效的预防措施。姜黄素是一种来自姜黄的膳食香料，具有出色的抗炎和神经保护作用。本文综述了姜黄素涉及生物学、药理学和药物化学的关键特征，并讨论了其与 MS 病理生理进展的潜在相关性。
