表没食子儿茶素没食子酸酯对人体皮肤的抗血管生成作用。
Anti-angiogenic effects of epigallocatechin-3-gallate in human skin.
作者信息
Domingo Diana Santo, Camouse Melissa M, Hsia Andrew H, Matsui Mary, Maes Daniel, Ward Nicole L, Cooper Kevin D, Baron Elma D
机构信息
University Hospitals Case Medical Center, Department of Dermatology, Cleveland, OH 44106, USA.
出版信息
Int J Clin Exp Pathol. 2010 Aug 5;3(7):705-9.
Epigallocatechin-3-gallate (EGCG) is the main polyphenol component of green tea. This compound exhibits antioxidant, immunomodulatory, photoprotective, anti-angiogenic, and anti-inflammatory properties. We conducted a small randomized, double blind, split face trial using a cream containing 2.5% w/w of EGCG. Four healthy volunteers with significant erythema and telangiectasia on the face applied EGCG cream to one side of the face, and vehicle control cream to the other, twice daily for six weeks. After six weeks, biopsies were taken from EGCG and vehicle treated sites. Immunohistochemistry was used to measure VEGF and HIF-1 α. HIF-1 α expression was decreased in EGCG treated sites, such that 28.4% of the epidermis showed positive staining in vehicle treated vs. 13.8% in EGCG treated sites (p<0.001). A similar decrease in VEGF expression was found (6.7% in EGCG vs. 11.0%in in vehicle-treated skin (p<0.005). EGCG topical treatments influence HIF-1 α induction and VEGF expression and may serve as a potential agent in the prevention of telangiectasias.
表没食子儿茶素-3-没食子酸酯（EGCG）是绿茶的主要多酚成分。该化合物具有抗氧化、免疫调节、光保护、抗血管生成和抗炎特性。我们进行了一项小型随机、双盲、半脸试验，使用了一种含有2.5%w/w EGCG的乳膏。四名面部有明显红斑和毛细血管扩张的健康志愿者，每天两次在一侧面部涂抹EGCG乳膏，另一侧涂抹赋形剂对照乳膏，持续六周。六周后，从EGCG处理部位和赋形剂处理部位取活检组织。采用免疫组织化学法检测血管内皮生长因子（VEGF）和缺氧诱导因子-1α（HIF-1α）。在EGCG处理部位，HIF-1α表达降低，赋形剂处理部位表皮有28.4%呈阳性染色，而EGCG处理部位为13.8%（p<0.001）。VEGF表达也有类似程度的降低（EGCG处理皮肤中为6.7%，赋形剂处理皮肤中为11.0%，p<0.005）。EGCG局部治疗可影响HIF-1α的诱导和VEGF表达，可能是预防毛细血管扩张的潜在药物。
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