Zheng Xin-Qiang, Zhang Xue-Han, Gao Han-Qing, Huang Lan-Ying, Ye Jing-Jing, Ye Jian-Hui, Lu Jian-Liang, Ma Shi-Cheng, Liang Yue-Rong
Tea Research Institute, Zhejiang University, #866, Yuhangtang Road, Hangzhou 310058, China.
Wuzhou Liubao Tea Research Association, #18, Sanlong Avenue, Changzhou District, Wuzhou 543001, China.
Antioxidants (Basel). 2024 Dec 10;13(12):1506. doi: 10.3390/antiox13121506.
Green tea catechins (GTCs) are a group of bioactive polyphenolic compounds found in fresh tea leaves ( (L.) O. Kuntze). They have garnered significant attention due to their diverse health benefits and potential therapeutic applications, including as antioxidant and sunscreen agents. Human skin serves as the primary barrier against various external aggressors, including pathogens, pollutants, and harmful ultraviolet radiation (UVR). Skin aging is a complex biological process influenced by intrinsic factors such as genetics and hormonal changes, as well as extrinsic factors like environmental stressors, among which UVR plays a pivotal role in accelerating skin aging and contributing to various dermatological conditions. Research has demonstrated that GTCs possess potent antioxidant properties that help neutralize free radicals generated by oxidative stress. This action not only mitigates cellular damage but also supports the repair mechanisms inherent in human skin. Furthermore, GTCs exhibit anti-carcinogenic effects by inhibiting pathways involved in tumor promotion and progression. GTCs have been shown to exert anti-inflammatory effects through modulation of inflammatory signaling pathways. Chronic inflammation is known to contribute significantly to both premature aging and various dermatological diseases such as psoriasis or eczema. By regulating these pathways effectively, GTCs may alleviate symptoms associated with inflammatory conditions. GTCs can enhance wound healing processes by stimulating angiogenesis. They also facilitate DNA repair mechanisms within dermal fibroblasts exposed to damaging agents. The photoprotective properties attributed to GTCs further underscore their relevance in skincare formulations aimed at preventing sun-induced damage. Their ability to screen UV light helps shield underlying tissues from harmful rays. This review paper aims to comprehensively examine the beneficial effects of GTCs on skin health through an analysis encompassing in vivo and in vitro studies alongside insights into molecular mechanisms underpinning these effects. Such knowledge could pave the way for the development of innovative strategies focused on harnessing natural compounds like GTCs for improved skincare solutions tailored to combat environmental stresses faced by the human epidermis.
绿茶儿茶素（GTCs）是一类存在于新鲜茶叶（(L.) O. Kuntze）中的生物活性多酚化合物。由于其多样的健康益处和潜在的治疗应用，包括作为抗氧化剂和防晒剂，它们受到了广泛关注。人体皮肤是抵御各种外部侵害的主要屏障，这些侵害包括病原体、污染物和有害紫外线辐射（UVR）。皮肤衰老是一个复杂的生物学过程，受遗传和激素变化等内在因素以及环境压力源等外在因素影响，其中UVR在加速皮肤衰老和引发各种皮肤病方面起着关键作用。研究表明，GTCs具有强大的抗氧化特性，有助于中和氧化应激产生的自由基。这种作用不仅减轻细胞损伤，还支持人体皮肤固有的修复机制。此外，GTCs通过抑制肿瘤促进和进展相关途径表现出抗癌作用。已证明GTCs通过调节炎症信号通路发挥抗炎作用。已知慢性炎症会显著导致过早衰老和各种皮肤病，如银屑病或湿疹。通过有效调节这些途径，GTCs可能减轻与炎症相关的症状。GTCs可通过刺激血管生成来促进伤口愈合过程。它们还促进暴露于损伤剂的真皮成纤维细胞内的DNA修复机制。GTCs的光保护特性进一步凸显了它们在旨在预防阳光引起的损伤的护肤品配方中的相关性。它们筛选紫外线的能力有助于保护深层组织免受有害射线的伤害。这篇综述文章旨在通过分析体内和体外研究以及对这些作用背后分子机制的见解，全面研究GTCs对皮肤健康的有益作用。这些知识可为开发创新策略铺平道路，这些策略专注于利用像GTCs这样的天然化合物，以开发针对人类表皮所面临环境压力的改良护肤品解决方案。
