Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 117543, Singapore.
Chem Commun (Camb). 2010 Oct 21;46(39):7406-8. doi: 10.1039/c0cc02366c. Epub 2010 Sep 8.
With the emerging interest in optical in vivo imaging, there is an increasing demand of photostable near-infrared (NIR) dyes. Herein we report the rational design of an amine tricarbocyanine structure with improved photostability (CyNA) and its combinatorial derivatization to render CyNA-414 as a NIR-fluorescent dye with stronger emission intensity and higher photostability than the NIR standard IndoCyanine Green (ICG).
随着对活体光学成像的兴趣日益浓厚，人们对光稳定性近红外 (NIR) 染料的需求也在不断增加。在此，我们报告了一种胺三碳菁结构的合理设计，该结构具有改进的光稳定性 (CyNA)，并对其进行组合衍生，得到 CyNA-414 作为一种近红外荧光染料，其发射强度比近红外标准吲哚菁绿 (ICG)更强，光稳定性更高。
