钯催化 2-(炔基)芳基异氰酸酯与苄醇的串联反应合成 3,3-二取代氧吲哚
Synthesis of 3,3-disubstituted oxindoles by palladium-catalyzed tandem reaction of 2-(alkynyl)aryl isocyanates with benzylic alcohols.
机构信息
Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan.
出版信息
Org Lett. 2010 Oct 15;12(20):4584-7. doi: 10.1021/ol101892b.
PMID:20831244
Abstract
A palladium complex sequentially promoted two mechanistically distinct reactions, the first, cyclization of 2-(alkynyl)aryl isocyanates with benzylic alcohols, and the second, [1,3] rearrangement of a benzyl group from oxygen to carbon, furnishing 3,3-disubstituted oxindoles in one pot.
摘要
钯配合物依次促进了两种在机理上不同的反应，第一，2-(炔基)芳基异氰酸酯与苄醇的环化反应，第二，苄基从氧到碳的[1,3]重排反应，一锅法得到 3,3-二取代的氧吲哚。
Zotero 插件