Department of Plant Pathology, University of California, Davis, CA 95616, USA.
Trends Plant Sci. 2010 Nov;15(11):595-9. doi: 10.1016/j.tplants.2010.08.004. Epub 2010 Sep 9.
Determination of gene function is particularly problematic when studying large-gene families because redundancy limits the ability to assess the contributions of individual genes experimentally. Phylogenomics is a phylogenetic approach used in comparative genomics to predict the biological functions of members of large gene-families by assessing the similarity among gene products. In this report, we describe the application of the Rice Kinase Database for elucidating functions of individual members of this gene family.
当研究大型基因家族时，确定基因功能特别成问题，因为冗余限制了从实验角度评估个别基因贡献的能力。系统发生基因组学是一种比较基因组学中使用的系统发生方法，通过评估基因产物之间的相似性来预测大型基因家族成员的生物功能。在本报告中，我们描述了应用水稻激酶数据库阐明该基因家族个别成员的功能。
