合成角型卤代顺式稠合双环酮的狄尔斯-阿尔德反应路线：易于获得的环烯酮中间体。
Diels-Alder routes to angularly halogenated cis-fused bicyclic ketones: Readily accessible cyclynone intermediates.
作者信息
Lee Jun Hee, Danishefsky Samuel J
机构信息
Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027.
出版信息
Tetrahedron Lett. 2010 Sep 1;51(35):4653-4654. doi: 10.1016/j.tetlet.2010.06.135.
Abstract
We have developed an efficient Lewis acid-catalyzed Diels-Alder route to a series of cis-fused bicyclic ketones bearing quaternary halogenation at the angular position. We have also developed a Diels-Alder based one-flask method for the regioselective preparation of TBS-protected 6-hydroxy tetralone and 5-hydroxy indanone derivatives.
摘要
我们已经开发出一种高效的路易斯酸催化的狄尔斯-阿尔德反应路线，用于合成一系列在角位带有季碳卤代的顺式稠合双环酮。我们还开发了一种基于狄尔斯-阿尔德反应的单瓶法，用于区域选择性制备TBS保护的6-羟基四氢萘酮和5-羟基茚满酮衍生物。
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