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Sunscreens with Titanium Dioxide (TiO(2)) Nano-Particles: A Societal Experiment.含二氧化钛(TiO₂)纳米颗粒的防晒霜:一项社会实验。
Nanoethics. 2010 Aug;4(2):103-113. doi: 10.1007/s11569-010-0090-y. Epub 2010 Jun 20.
2
Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano- and submicron-size TiO2 particles.防晒霜配方中的纳米和亚微米级 TiO2 颗粒,其二氧化钛几乎不会穿透皮肤。
Toxicol Sci. 2010 May;115(1):156-66. doi: 10.1093/toxsci/kfq041. Epub 2010 Feb 15.
3
Human safety review of "nano" titanium dioxide and zinc oxide.“纳米”二氧化钛和氧化锌的人体安全评估。
Photochem Photobiol Sci. 2010 Apr;9(4):495-509. doi: 10.1039/b9pp00180h.
4
Nano-sized cosmetic formulations or solid nanoparticles in sunscreens: a risk to human health?纳米级化妆品配方或防晒霜中的固体纳米颗粒:对人类健康的风险?
Arch Toxicol. 2012 Jul;86(7):1063-75. doi: 10.1007/s00204-012-0831-5. Epub 2012 Mar 31.
5
Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety.皮肤上出现灰色黏液?纳米技术、化妆品与防晒霜安全问题。
Crit Rev Toxicol. 2007 Mar;37(3):251-77. doi: 10.1080/10408440601177780.
6
Particle size determination of sunscreens formulated with various forms of titanium dioxide.测定不同形式的二氧化钛所制防晒霜的颗粒大小。
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Interaction of nano-TiO2 with lysozyme: insights into the enzyme toxicity of nanosized particles.纳米 TiO2 与溶菌酶的相互作用:纳米颗粒对酶毒性的深入了解。
Environ Sci Pollut Res Int. 2010 Mar;17(3):798-806. doi: 10.1007/s11356-009-0153-1. Epub 2009 Apr 24.
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Photoprotection in the era of nanotechnology.纳米技术时代的光保护
Semin Cutan Med Surg. 2011 Dec;30(4):210-3. doi: 10.1016/j.sder.2011.07.006.
9
Reproductive and behavioral responses of earthworms exposed to nano-sized titanium dioxide in soil.土壤中纳米二氧化钛对蚯蚓生殖和行为的响应。
Environ Toxicol Chem. 2012 Jan;31(1):184-93. doi: 10.1002/etc.714. Epub 2011 Nov 18.
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TiO₂-based nanoparticles released in water from commercialized sunscreens in a life-cycle perspective: structures and quantities.从生命周期角度来看商业化防晒霜在水中释放的基于 TiO₂ 的纳米颗粒:结构和数量。
Environ Pollut. 2011 Jun;159(6):1543-50. doi: 10.1016/j.envpol.2011.03.003. Epub 2011 Apr 8.

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TiO nanoparticles improves cadmium toxicity tolerance in Hemerocallis citrina Baroni by modulating photosynthetic and antioxidative profile.二氧化钛纳米颗粒通过调节光合作用和抗氧化特性提高金针菜对镉毒性的耐受性。
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Potential applications for photoacoustic imaging using functional nanoparticles: A comprehensive overview.使用功能性纳米颗粒的光声成像的潜在应用:全面概述。
Heliyon. 2024 Jul 17;10(15):e34654. doi: 10.1016/j.heliyon.2024.e34654. eCollection 2024 Aug 15.
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TiO-Alginate-Chitosan-Based Composites for Skin Tissue Engineering Applications.用于皮肤组织工程应用的基于二氧化钛-海藻酸盐-壳聚糖的复合材料
Gels. 2024 May 22;10(6):358. doi: 10.3390/gels10060358.
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From Nano Backlash to Public Indifference: Some Reflections on French Public Dialogues on Nanotechnology.从纳米技术的强烈反对到公众的漠不关心:关于法国纳米技术公共对话的一些思考
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A Protein and Membrane Integrity Study of TiO Nanoparticles-Induced Mitochondrial Dysfunction and Prevention by Iron Incorporation.铁掺杂对 TiO<sub>2</sub>纳米颗粒诱导的线粒体功能障碍的蛋白和膜完整性研究及预防
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Toxicity Evaluation of TiO Nanoparticles on the 3D Skin Model: A Systematic Review.TiO纳米颗粒对3D皮肤模型的毒性评估:一项系统综述。
Front Bioeng Biotechnol. 2020 Jun 10;8:575. doi: 10.3389/fbioe.2020.00575. eCollection 2020.
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Study of mitochondrial swelling, membrane fluidity and ROS production induced by nano-TiO and prevented by Fe incorporation.纳米二氧化钛诱导并由铁掺入所预防的线粒体肿胀、膜流动性及活性氧生成的研究
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The effect of micro-sized titanium dioxide on WM-266-4 metastatic melanoma cell line.微尺寸二氧化钛对 WM-266-4 转移性黑色素瘤细胞系的影响。
Bosn J Basic Med Sci. 2019 Feb 12;19(1):60-66. doi: 10.17305/bjbms.2018.3674.
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Synthesis and characterization of Zr- and Hf-doped nano-TiO as internal standards for analytical quantification of nanomaterials in complex matrices.用于复杂基质中纳米材料分析定量的锆和铪掺杂纳米二氧化钛内标的合成与表征
R Soc Open Sci. 2018 Jun 6;5(6):171884. doi: 10.1098/rsos.171884. eCollection 2018 Jun.
10
Effects of differently shaped TiONPs (nanospheres, nanorods and nanowires) on the in vitro model (Caco-2/HT29) of the intestinal barrier.不同形状的 TiO2 纳米粒子(球形、棒形和线形)对肠道屏障体外模型(Caco-2/HT29)的影响。
Part Fibre Toxicol. 2018 Aug 7;15(1):33. doi: 10.1186/s12989-018-0269-x.

本文引用的文献

1
Sensors as tools for quantitation, nanotoxicity and nanomonitoring assessment of engineered nanomaterials.传感器作为工程纳米材料定量、纳米毒性和纳米监测评估的工具。
J Environ Monit. 2009 Oct;11(10):1782-800. doi: 10.1039/b912860c. Epub 2009 Sep 14.
2
Are environmental regulations keeping up with innovation? A case study of the nanotechnology industry.环境法规是否跟上了创新步伐?以纳米技术产业为例的一项案例研究。
Ecotoxicol Environ Saf. 2009 Jul;72(5):1327-30. doi: 10.1016/j.ecoenv.2009.04.003. Epub 2009 May 6.
3
Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide.在确定超细微和细碳黑的肺部毒性时,给予的粒子表面积与质量的关系:与超细微二氧化钛的比较。
Part Fibre Toxicol. 2009 May 4;6:15. doi: 10.1186/1743-8977-6-15.
4
Influence of ionic strength, pH, and cation valence on aggregation kinetics of titanium dioxide nanoparticles.离子强度、pH值和阳离子价态对二氧化钛纳米颗粒聚集动力学的影响。
Environ Sci Technol. 2009 Mar 1;43(5):1354-9. doi: 10.1021/es802628n.
5
Comparison of molecular and histological changes in zebrafish gills exposed to metallic nanoparticles.暴露于金属纳米颗粒的斑马鱼鳃中分子和组织学变化的比较。
Toxicol Sci. 2009 Feb;107(2):404-15. doi: 10.1093/toxsci/kfn256. Epub 2008 Dec 10.
6
Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO(2) nanoparticles.经鼻滴注二氧化钛纳米颗粒后随时间变化的易位及对中枢神经系统的潜在损害
Toxicology. 2008 Dec 5;254(1-2):82-90. doi: 10.1016/j.tox.2008.09.014. Epub 2008 Sep 25.
7
In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR.量子点纳米颗粒在小鼠模型中的体内皮肤渗透:紫外线辐射的影响
Nano Lett. 2008 Sep;8(9):2779-87. doi: 10.1021/nl801323y. Epub 2008 Aug 8.
8
Nanotechnology and health safety--toxicity and risk assessments of nanostructured materials on human health.纳米技术与健康安全——纳米结构材料对人类健康的毒性及风险评估
J Nanosci Nanotechnol. 2007 Sep;7(9):3048-70. doi: 10.1166/jnn.2007.922.
9
Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications.二氧化钛纳米材料:合成、性质、改性及应用
Chem Rev. 2007 Jul;107(7):2891-959. doi: 10.1021/cr0500535. Epub 2007 Jun 23.
10
Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety.皮肤上出现灰色黏液?纳米技术、化妆品与防晒霜安全问题。
Crit Rev Toxicol. 2007 Mar;37(3):251-77. doi: 10.1080/10408440601177780.

含二氧化钛(TiO₂)纳米颗粒的防晒霜:一项社会实验。

Sunscreens with Titanium Dioxide (TiO(2)) Nano-Particles: A Societal Experiment.

作者信息

Jacobs Johannes F, van de Poel Ibo, Osseweijer Patricia

出版信息

Nanoethics. 2010 Aug;4(2):103-113. doi: 10.1007/s11569-010-0090-y. Epub 2010 Jun 20.

DOI:10.1007/s11569-010-0090-y
PMID:20835397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2933802/
Abstract

The risks of novel technologies, such as nano(bio)technology cannot be fully assessed due to the existing uncertainties surrounding their introduction into society. Consequently, the introduction of innovative technologies can be conceptualised as a societal experiment, which is a helpful approach to evaluate moral acceptability. This approach is illustrated with the marketing of sunscreens containing nano-sized titanium dioxide (TiO(2)) particles. We argue that the marketing of this TiO(2) nanomaterial in UV protective cosmetics is ethically undesirable, since it violates four reasonable moral conditions for societal experimentation (absence of alternatives, controllability, limited informed consent, and continuing evaluation). To remedy the current way nano-sized TiO(2) containing sunscreens are utilised, we suggest five complementing actions (closing the gap, setup monitoring tools, continuing review, designing for safety, and regulative improvements) so that its marketing can become more acceptable.

摘要

由于纳米(生物)技术等新技术引入社会时存在诸多不确定性,其风险无法得到全面评估。因此,创新技术的引入可被视为一项社会实验,这是评估道德可接受性的一种有益方法。含有纳米级二氧化钛(TiO₂)颗粒的防晒霜的营销就说明了这种方法。我们认为,这种TiO₂纳米材料在紫外线防护化妆品中的营销在伦理上是不可取的,因为它违反了社会实验的四个合理道德条件(没有替代方案、可控性、有限知情同意和持续评估)。为了改进目前含纳米级TiO₂防晒霜的使用方式,我们建议采取五项补充行动(弥补差距、建立监测工具、持续审查、安全设计和监管改进),以便其营销能变得更可接受。