Department of Nanoengineering, University of CA, San Diego, CA, USA.
Nanoscale. 2010 Dec;2(12):2530-7. doi: 10.1039/c0nr00430h. Epub 2010 Sep 13.
In the last decade, "small" and "integrated" have been keywords in the field of device fabrication as the desire to exploit nanoscale phenomena and make electronic, photonic and magnetic arrays has grown. In an effort to improve resolution and control costs, much work has been dedicated to developing alternatives to conventional microfabrication technology. For this purpose, biomolecular assembly and DNA nanotechnology in particular are appealing owing to their inherent size and capacity for molecular recognition. Herein, we review recent achievements in DNA-based directed assembly on substrates. These include novel methods for patterning and depositing nanomaterials on DNA-modified surfaces as well as using synthetic DNA nanostructures such as DNA tiles and origami as templates to direct the assembly of nanoscale components. Particular attention is paid to integrating self-assembly with top-down lithography, and some possible directions for future work are discussed.
在过去的十年中，“小”和“集成”一直是器件制造领域的关键词，因为人们越来越希望利用纳米现象并制造电子、光子和磁性阵列。为了提高分辨率和控制成本，人们致力于开发替代传统微制造技术的方法。为此，生物分子组装和 DNA 纳米技术特别有吸引力，因为它们具有内在的尺寸和分子识别能力。在此，我们综述了基于 DNA 的在衬底上定向组装的最新进展。这些进展包括在 DNA 修饰表面上图案化和沉积纳米材料的新方法，以及使用合成 DNA 纳米结构（如 DNA 片和折纸）作为模板来指导纳米级组件的组装。特别关注自组装与自上而下光刻的集成，讨论了一些未来工作的可能方向。
