Bol A, Vanmelckenbeke P, Michel C, Cogneau M, Goffinet A M
Positron Tomography Laboratory, University of Louvain, Belgium.
Eur J Nucl Med. 1990;17(5):234-41. doi: 10.1007/BF00812363.
A method is presented for the measurement of cerebral blood flow (CBF) with a bolus of water labelled with oxygen 15. The method, which has been evaluated in normal volunteers, is based on Kety's model, with two additional parameters to account for the difference in the time of tracer arrival in the radial and carotid arteries ("delay") and for dispersion of the tracer in the body and/or blood counting systems. It combines the advantages of: (i) dynamic data collection for estimation of delay and dispersion; (ii) robustness and linearity of CBF estimates with an integral method; and (iii) simplicity of continuous external monitoring of arterial blood radioactivity, particularly with repeated measurements. An optimized protocol is proposed for routine applications in neurological and neurophysiological studies.
本文介绍了一种利用含15氧的水团注测量脑血流量（CBF）的方法。该方法已在正常志愿者中进行评估，它基于凯蒂模型，增加了两个参数，用于解释示踪剂到达桡动脉和颈动脉的时间差异（“延迟”）以及示踪剂在体内和/或血液计数系统中的弥散。它结合了以下优点：（i）通过动态数据采集来估计延迟和弥散；（ii）采用积分法时CBF估计值的稳健性和线性；（iii）动脉血放射性连续外部监测的简便性，尤其是重复测量时。本文还提出了一种优化方案，用于神经学和神经生理学研究中的常规应用。
