Bozhko G Kh, Voloshin P V, Chursina V S
Vopr Med Khim. 1988 Sep-Oct;34(5):39-43.
Content of cholesterol and binding of its labelled analogue was studied in guinea pigs tissues after hypercholesterolemia, ethanol intoxication and their combined action within 30, 60 and 90 days. Long-term consumption of cholesterol and chronic alcoholization caused accumulation of the steroid but in abundance of exogenous cholesterol its concentration was increased mainly in liver tissue and blood serum, whole in ethanol intoxication--in brain and kidney tissues. Chronic alcoholization contributed to cholesterosis development; the increase in cholesterol content was accompanied by a decrease in its renovation, especially distinct in liver and heart tissues. Combined effect of cholesterol and ethanol on liver tissue was detected within 60 days; at the same time, simultaneous effect of cholesterol and ethanol caused more pronounced impairments in liver tissue within 90 days as compared with the individual action of these drugs. Concentration of cholesterol was not altered in heart muscle after administration either cholesterol or ethanol, while its content was increased after the drugs simultaneous effect.
研究了高胆固醇血症、乙醇中毒及其联合作用30、60和90天后豚鼠组织中胆固醇的含量及其标记类似物的结合情况。长期摄入胆固醇和慢性酒精化会导致类固醇的积累，但在外源性胆固醇丰富的情况下，其浓度主要在肝脏组织和血清中升高，而在乙醇中毒时则在脑和肾组织中升高。慢性酒精化促进了胆汁淤积的发展；胆固醇含量的增加伴随着其更新的减少，在肝脏和心脏组织中尤为明显。胆固醇和乙醇对肝脏组织的联合作用在60天内被检测到；同时，与这些药物的单独作用相比，胆固醇和乙醇的同时作用在90天内对肝脏组织造成了更明显的损害。给予胆固醇或乙醇后，心肌中胆固醇的浓度没有改变，而在药物同时作用后其含量增加。
