通过迈克尔加成反应制备和表征水溶性壳聚糖衍生物。

Preparation and characterization of water-soluble chitosan derivative by Michael addition reaction.

机构信息

Changzhou University, Changzhou 213164, PR China.

出版信息

Int J Biol Macromol. 2010 Dec 1;47(5):696-9. doi: 10.1016/j.ijbiomac.2010.09.002. Epub 2010 Sep 15.

DOI:10.1016/j.ijbiomac.2010.09.002

PMID:20837054

Abstract

The efficient procedure to prepare novel water-soluble chitosan derivative was established by Michael addition reaction to introduce sodium allylsulfonate into the chitosan at mild condition. The chemical structure of the chitosan derivative was characterized by FT-IR, (1)H NMR and Elemental analysis. The degree of substitution (DS) was calculated by Elemental analysis. The chitosan derivative exhibited an excellent solubility in the distilled water. The physical properties were analyzed by XRD and TG. The XRD study indicated that the crystallinity of chitosan derivative decreased. The thermal analysis showed that chitosan derivative had lower thermal stability than chitosan.

摘要

建立了一种通过迈克尔加成反应在温和条件下将烯丙基磺酸钠引入壳聚糖中的新型水溶性壳聚糖衍生物的有效制备方法。通过傅里叶变换红外光谱（FT-IR）、（1）H 核磁共振和元素分析对壳聚糖衍生物的化学结构进行了表征。通过元素分析计算取代度（DS）。壳聚糖衍生物在蒸馏水中具有优异的溶解性。通过 X 射线衍射（XRD）和热重分析（TG）对其物理性能进行了分析。XRD 研究表明壳聚糖衍生物的结晶度降低。热分析表明壳聚糖衍生物的热稳定性低于壳聚糖。