Unità Operativa Chirurgia Oftalmica, Azienda Ospedaliera-Universitaria Pisana, Stabilimento Ospedaliero di Cisanello, Via Paradisa, 2 - Cisanello, Pisa, 56124, Italy.
Graefes Arch Clin Exp Ophthalmol. 2011 Mar;249(3):361-7. doi: 10.1007/s00417-010-1503-x. Epub 2010 Sep 15.
To report the results of a prospective pilot study using a new heavy agent, HWS-45 3000, as endotamponade in complicated inferior retinal detachment.
Ten consecutive patients satisfying the enrolment criteria were studied. Inclusion criteria was the presence of inferior retinal detachment complicated by PVR grade C2 or more (according to Retina Society classification) or retinal detachment due to penetrating ocular trauma or giant retinal tears. Heavy silicone oil was injected at the end of surgery after peeling of retinal membranes and/or retinotomy. Follow-up protocol visits were scheduled at 1 day, 1 week, 1 month, and 2 months after the initial surgery and 1 week, 1 month and 6 months after HWS-45 3000 removal surgery. Oil removal was planned after about 2 months from the main surgery.
At the 1-month protocol visit, eight eyes presented retinal reattachment and two eyes presented a retinal detachment not involving the posterior pole. Visual acuity ranged from 2.2 logMAR to 1.0 (mean: 1.45, SD: 0.53). Oil removal surgery was scheduled about 60 days postoperatively. All eyes required additional endolaser treatment during removal surgery, and four eyes epiretinal membrane peeling. In two eyes that presented retinal detachment not involving the posterior pole, tamponading with 5700 cSt silicone oil was necessary. At 3- and 6-month protocol visits, all patients presented retina reattached; two eyes had silicone oil as internal tamponade.
From our first results, HWS-45 3000 appears to be a well-tolerated heavy oil suitable for the treatment of complicated inferior retinal detachment.
报告使用新型重硅油 HWS-453000 作为眼内填塞剂治疗复杂下视网膜脱离的前瞻性初步研究结果。
连续纳入 10 例符合纳入标准的患者。纳入标准为存在下视网膜脱离，且合并 C2 级以上的增生性玻璃体视网膜病变（根据视网膜学会分类）或穿透性眼外伤或巨大视网膜裂孔引起的视网膜脱离。在视网膜膜剥除和/或视网膜切开术后，于手术末期注入重硅油。术后第 1、1 周、1 个月和 2 个月，以及硅油取出术后 1 周、1 个月和 6 个月进行随访。计划在主手术后约 2 个月行硅油取出术。
在 1 个月的随访中，8 只眼视网膜复位，2 只眼出现不涉及后极部的视网膜脱离。视力范围为 2.2logMAR 至 1.0（平均：1.45，SD：0.53）。硅油取出术安排在术后约 60 天进行。所有眼在取出手术中均需行额外的眼内激光治疗，其中 4 眼行视网膜膜剥除。在 2 只不涉及后极部的视网膜脱离眼，需要用 5700cSt 硅油进行填塞。在 3 个月和 6 个月的随访中，所有患者均出现视网膜复位；2 眼硅油内填塞。
根据我们的初步结果，HWS-453000 似乎是一种耐受性良好的重硅油，适用于治疗复杂的下视网膜脱离。
