Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
Org Lett. 2010 Oct 15;12(20):4664-6. doi: 10.1021/ol102007d.
Screening for anti-influenza virus activity in compounds isolated from Streptomyces sp. RI18, which was isolated using the membrane filter method, uncovered a novel compound, JBIR-68 (1), which contains a unique skeleton. Its structure was established by extensive NMR and MS analyses. In addition, 1 was synthesized to confirm the configuration of its sugar moiety. Compound 1 inhibited influenza virus growth in plaque assays.
采用膜过滤法从链霉菌 RI18 中分离得到的化合物进行抗流感病毒活性筛选，发现了一种新型化合物 JBIR-68（1），它含有独特的骨架。其结构通过广泛的 NMR 和 MS 分析确定。此外，还合成了 1 以确定其糖部分的构型。化合物 1 在蚀斑试验中抑制流感病毒的生长。
