Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego , La Jolla, California 92093-0204, United States.
J Nat Prod. 2013 Sep 27;76(9):1815-8. doi: 10.1021/np400351t. Epub 2013 Aug 29.
Farnesides A and B (1, 2), linear sesquiterpenoids connected by ether links to a ribose dihydrouracil nucleoside, were isolated from a marine-derived Streptomyces sp., strain CNT-372, grown in saline liquid culture. The structures of the new compounds were assigned by comprehensive spectroscopic analysis primarily involving 1D and 2D NMR analysis and by comparison of spectroscopic data to the recently reported ribose nucleoside JBIR-68 (3). The farnesides are only the second example of this exceedingly rare class of microbial terpenoid nucleoside metabolites. Farneside A (1) was found to have modest antimalarial activity against the parasite Plasmodium falciparum.
法内昔斯 A 和 B（1、2），是通过醚键连接到核糖二氢尿嘧啶核苷的线性倍半萜烯，从海洋来源的链霉菌属 CNT-372 菌株的盐溶液培养物中分离得到。新化合物的结构通过综合光谱分析确定，主要涉及 1D 和 2D NMR 分析，并通过与最近报道的核糖核苷 JBIR-68（3）的光谱数据进行比较。法内昔斯是这种极其罕见的微生物萜类核苷代谢物的仅有第二例。法内昔斯 A（1）被发现对寄生虫疟原虫具有中等的抗疟活性。
