Mocan T, Clichici S, Agoşton-Coldea L, Mocan L, Simon S, Ilie I R, Biriş A R, Mureşan A
University of Medicine and Pharmacy Iuliu Haţieganu, Cluj-Napoca, Romania.
Acta Physiol Hung. 2010 Sep;97(3):247-55. doi: 10.1556/APhysiol.97.2010.3.1.
Nanosized particles (NPs) have recently been proposed for extensive use, including into the biomedical field. As a result, research on toxicity and oxidative stress concerning the interaction of nanoparticle and the living organism has attracted increasing interest among specialists. Two different targets have been the motor of this type of research: 1) the safety concern regarding such NPs large-scale use along with the need to generate antidote solutions to possible adverse effects, 2) the idea of influencing oxidative damage and of using them for elaborating anticancer/antimicrobial therapies. Present study reviews recent research achievements within the proposed theme taking into account the nature and particularities of each type of nanoparticle.
纳米粒子（NPs）最近被提议广泛应用，包括在生物医学领域。因此，关于纳米粒子与生物体相互作用的毒性和氧化应激研究在专家中引起了越来越多的关注。这种研究类型的推动有两个不同的目标：1）对这类纳米粒子大规模使用的安全担忧以及产生应对可能不良反应的解毒解决方案的需求，2）影响氧化损伤并将其用于开发抗癌/抗菌疗法的想法。本研究考虑到每种纳米粒子的性质和特殊性，综述了在所提出主题内的近期研究成果。
