• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用功能化金纳米颗粒对多重耐药细菌进行激光热消融

Laser thermal ablation of multidrug-resistant bacteria using functionalized gold nanoparticles.

作者信息

Mocan Lucian, Tabaran Flaviu A, Mocan Teodora, Pop Teodora, Mosteanu Ofelia, Agoston-Coldea Lucia, Matea Cristian T, Gonciar Diana, Zdrehus Claudiu, Iancu Cornel

机构信息

3rd Department of General Surgery, "Iuliu Hatieganu" University of Medicine and Pharmacy; Department of Nanomedicine, "Octavian Fodor" Gastroenterology Institute.

Department of Pathology, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine.

出版信息

Int J Nanomedicine. 2017 Mar 23;12:2255-2263. doi: 10.2147/IJN.S124778. eCollection 2017.

DOI:10.2147/IJN.S124778
PMID:28356741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5367598/
Abstract

The issue of multidrug resistance (MDR) has become an increasing threat to public health. One alternative strategy against MDR bacteria would be to construct therapeutic vectors capable of physically damaging these microorganisms. Gold nanoparticles hold great promise for the development of such therapeutic agents, since the nanoparticles exhibit impressive properties, of which the most important is the ability to convert light into heat. This property has scientific significance since is exploited to develop nano-photothermal vectors to destroy bacteria at a molecular level. The present paper summarizes the latest advancements in the field of nanotargeted laser hyperthermia of MDR bacteria mediated by gold nanoparticles.

摘要

多重耐药性（MDR）问题已对公众健康构成日益严重的威胁。对抗多重耐药菌的一种替代策略是构建能够对这些微生物造成物理损伤的治疗载体。金纳米颗粒在开发此类治疗剂方面具有巨大潜力，因为这些纳米颗粒具有令人瞩目的特性，其中最重要的是能够将光转化为热的能力。这一特性具有科学意义，因为它被用于开发纳米光热载体，以在分子水平上破坏细菌。本文总结了金纳米颗粒介导的多重耐药菌纳米靶向激光热疗领域的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de9/5367598/48554f6cc110/ijn-12-2255Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de9/5367598/7ff8372c9117/ijn-12-2255Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de9/5367598/229bd9ca3d9e/ijn-12-2255Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de9/5367598/2023cbdc8561/ijn-12-2255Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de9/5367598/b9a32406dcae/ijn-12-2255Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de9/5367598/48554f6cc110/ijn-12-2255Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de9/5367598/7ff8372c9117/ijn-12-2255Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de9/5367598/229bd9ca3d9e/ijn-12-2255Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de9/5367598/2023cbdc8561/ijn-12-2255Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de9/5367598/b9a32406dcae/ijn-12-2255Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de9/5367598/48554f6cc110/ijn-12-2255Fig5.jpg

相似文献

1
Laser thermal ablation of multidrug-resistant bacteria using functionalized gold nanoparticles.使用功能化金纳米颗粒对多重耐药细菌进行激光热消融
Int J Nanomedicine. 2017 Mar 23;12:2255-2263. doi: 10.2147/IJN.S124778. eCollection 2017.
2
Assembled gold nanorods for the photothermal killing of bacteria.组装金纳米棒用于光热杀菌。
Colloids Surf B Biointerfaces. 2019 Jan 1;173:833-841. doi: 10.1016/j.colsurfb.2018.10.060. Epub 2018 Oct 23.
3
Laser and radiofrequency-induced hyperthermia treatment via gold-coated magnetic nanocomposites.金包覆磁性纳米复合材料的激光和射频诱导热疗。
Int J Nanomedicine. 2011;6:2155-65. doi: 10.2147/IJN.S23952. Epub 2011 Sep 28.
4
Gold nanoparticles decorated graphene oxide/nanocellulose paper for NIR laser-induced photothermal ablation of pathogenic bacteria.金纳米粒子修饰的氧化石墨烯/纳米纤维素纸用于近红外激光诱导的致病菌光热消融。
Carbohydr Polym. 2018 Oct 15;198:206-214. doi: 10.1016/j.carbpol.2018.06.074. Epub 2018 Jun 18.
5
Effective Targeted Photothermal Ablation of Multidrug Resistant Bacteria and Their Biofilms with NIR-Absorbing Gold Nanocrosses.近红外吸收金纳米交叉结构有效靶向光热消融耐多药细菌及其生物膜。
Adv Healthc Mater. 2016 Aug;5(16):2122-30. doi: 10.1002/adhm.201600346. Epub 2016 Jun 23.
6
Specific cell targeting with nanobody conjugated branched gold nanoparticles for photothermal therapy.利用偶联分支金纳米粒子的纳米抗体特异性靶向细胞用于光热治疗。
ACS Nano. 2011 Jun 28;5(6):4319-28. doi: 10.1021/nn1023363. Epub 2011 Jun 10.
7
EGF Functionalized Polymer-Coated Gold Nanoparticles Promote EGF Photostability and EGFR Internalization for Photothermal Therapy.表皮生长因子功能化的聚合物包覆金纳米颗粒促进表皮生长因子的光稳定性及表皮生长因子受体的内化以用于光热治疗。
PLoS One. 2016 Oct 27;11(10):e0165419. doi: 10.1371/journal.pone.0165419. eCollection 2016.
8
A new NIR-triggered doxorubicin and photosensitizer indocyanine green co-delivery system for enhanced multidrug resistant cancer treatment through simultaneous chemo/photothermal/photodynamic therapy.一种新型近红外触发的阿霉素和光敏剂吲哚菁绿共递送系统，通过同步化疗/光热/光动力疗法增强对多药耐药癌症的治疗。
Acta Biomater. 2017 Sep 1;59:170-180. doi: 10.1016/j.actbio.2017.06.026. Epub 2017 Jun 17.
9
An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy.一种用于感染部位靶向化疗-光热治疗的高效抗菌储库。
J Nanobiotechnology. 2018 Mar 16;16(1):23. doi: 10.1186/s12951-018-0348-z.
10
Photothermal killing of Staphylococcus aureus using antibody-targeted gold nanoparticles.利用抗体靶向金纳米颗粒对金黄色葡萄球菌进行光热杀伤
Int J Nanomedicine. 2015 Mar 18;10:1953-60. doi: 10.2147/IJN.S76150. eCollection 2015.

引用本文的文献

1
Advances in Photothermal Electrospinning: From Fiber Fabrication to Biomedical Application.光热静电纺丝技术的进展：从纤维制造到生物医学应用
Polymers (Basel). 2025 Jun 20;17(13):1725. doi: 10.3390/polym17131725.
2
Excellent antibacterial and anti-inflammatory efficacy of amoxicillin by AgNPs and their conjugates synthesized using crude flavonoid extracts.利用粗黄酮提取物合成的银纳米颗粒及其共轭物对阿莫西林具有优异的抗菌和抗炎功效。
Heliyon. 2024 Aug 23;10(17):e36752. doi: 10.1016/j.heliyon.2024.e36752. eCollection 2024 Sep 15.
3
Nano-Biotechnology for Bacteria Identification and Potent Anti-bacterial Properties: A Review of Current State of the Art.

本文引用的文献

1
Towards Effective Photothermal/Photodynamic Treatment Using Plasmonic Gold Nanoparticles.利用等离子体金纳米粒子实现有效的光热/光动力治疗
Int J Mol Sci. 2016 Aug 9;17(8):1295. doi: 10.3390/ijms17081295.
2
Synergistic Photothermal and Antibiotic Killing of Biofilm-Associated Using Targeted Antibiotic-Loaded Gold Nanoconstructs.利用靶向载抗生素金纳米结构对生物膜相关细菌进行协同光热和抗生素杀伤
ACS Infect Dis. 2016 Apr 8;2(4):241-250. doi: 10.1021/acsinfecdis.5b00117. Epub 2016 Feb 10.
3
Effective Targeted Photothermal Ablation of Multidrug Resistant Bacteria and Their Biofilms with NIR-Absorbing Gold Nanocrosses.
用于细菌鉴定和强大抗菌特性的纳米生物技术：当前技术水平综述
Nanomaterials (Basel). 2023 Sep 10;13(18):2529. doi: 10.3390/nano13182529.
4
Antibacterial Properties of Gold Nanoparticles in the Modification of Medical Implants: A Systematic Review.金纳米颗粒在医用植入物改性中的抗菌性能：一项系统综述
Pharmaceutics. 2022 Nov 30;14(12):2654. doi: 10.3390/pharmaceutics14122654.
5
The Antimicrobial Effect of Gold Quantum Dots and Femtosecond Laser Irradiation on the Growth Kinetics of Common Infectious Eye Pathogens: An In Vitro Study.金量子点和飞秒激光照射对常见眼部感染病原体生长动力学的抗菌作用：一项体外研究
Nanomaterials (Basel). 2022 Oct 26;12(21):3757. doi: 10.3390/nano12213757.
6
Carbon Nanotubes-Based Assays for Cancer Detection and Screening.基于碳纳米管的癌症检测与筛查分析方法
Pharmaceutics. 2022 Apr 3;14(4):781. doi: 10.3390/pharmaceutics14040781.
7
Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects.基于等离激元纳米粒子的肿瘤光热与光动力治疗：挑战与前景
Materials (Basel). 2022 Feb 21;15(4):1606. doi: 10.3390/ma15041606.
8
Effect of Temperature on Metronidazole Resistance in .温度对……中甲硝唑耐药性的影响
Front Microbiol. 2021 May 19;12:681911. doi: 10.3389/fmicb.2021.681911. eCollection 2021.
9
Gold Nanoparticles: Can They Be the Next Magic Bullet for Multidrug-Resistant Bacteria?金纳米颗粒：它们会成为抗多重耐药菌的下一个神奇药物吗？
Nanomaterials (Basel). 2021 Jan 26;11(2):312. doi: 10.3390/nano11020312.
10
Pulling the Brakes on Fast and Furious Multiple Drug-Resistant (MDR) Bacteria.遏制快速传播和耐药性多重耐药（MDR）细菌。
Int J Mol Sci. 2021 Jan 16;22(2):859. doi: 10.3390/ijms22020859.
近红外吸收金纳米交叉结构有效靶向光热消融耐多药细菌及其生物膜。
Adv Healthc Mater. 2016 Aug;5(16):2122-30. doi: 10.1002/adhm.201600346. Epub 2016 Jun 23.
4
Gold Nanoparticle Labeling Based ICP-MS Detection/Measurement of Bacteria, and Their Quantitative Photothermal Destruction.基于金纳米颗粒标记的电感耦合等离子体质谱法检测/测量细菌及其定量光热破坏
J Mater Chem B. 2015 May 7;3(17):3573-3582. doi: 10.1039/C5TB00223K. Epub 2015 Mar 23.
5
Photothermal treatment of liver cancer with albumin-conjugated gold nanoparticles initiates Golgi Apparatus-ER dysfunction and caspase-3 apoptotic pathway activation by selective targeting of Gp60 receptor.用白蛋白共轭金纳米颗粒对肝癌进行光热治疗，通过选择性靶向Gp60受体引发高尔基体-内质网功能障碍和半胱天冬酶-3凋亡途径激活。
Int J Nanomedicine. 2015 Aug 26;10:5435-45. doi: 10.2147/IJN.S86495. eCollection 2015.
6
Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging.利用高光谱成像检测原位胰腺腺癌中的磷脂酰胆碱包被金纳米颗粒
PLoS One. 2015 Jun 5;10(6):e0129172. doi: 10.1371/journal.pone.0129172. eCollection 2015.
7
In Vitro Administration of Gold Nanoparticles Functionalized with MUC-1 Protein Fragment Generates Anticancer Vaccine Response via Macrophage Activation and Polarization Mechanism.通过巨噬细胞激活和极化机制，用MUC-1蛋白片段功能化的金纳米颗粒的体外给药产生抗癌疫苗反应。
J Cancer. 2015 May 15;6(6):583-92. doi: 10.7150/jca.11567. eCollection 2015.
8
Photothermal killing of Staphylococcus aureus using antibody-targeted gold nanoparticles.利用抗体靶向金纳米颗粒对金黄色葡萄球菌进行光热杀伤
Int J Nanomedicine. 2015 Mar 18;10:1953-60. doi: 10.2147/IJN.S76150. eCollection 2015.
9
Engineering nanoparticles to silence bacterial communication.工程纳米粒子以沉默细菌通讯。
Front Microbiol. 2015 Mar 10;6:189. doi: 10.3389/fmicb.2015.00189. eCollection 2015.
10
Gold Nanoparticles: Recent Advances in the Biomedical Applications.金纳米颗粒：生物医学应用的最新进展
Cell Biochem Biophys. 2015 Jul;72(3):771-5. doi: 10.1007/s12013-015-0529-4.