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纳米技术在转移性癌症治疗中的应用：当前成果与未来研究趋势

Nanotechnology in metastatic cancer treatment: Current Achievements and Future Research Trends.

作者信息

Gonciar Diana, Mocan Teodora, Matea Cristian Tudor, Zdrehus Claudiu, Mosteanu Ofelia, Mocan Lucian, Pop Teodora

机构信息

Third Surgery Clinic, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania.

Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology "Prof.Dr. Octavian Fodor" Cluj-Napoca , Romania.

出版信息

J Cancer. 2019 Feb 7;10(6):1358-1369. doi: 10.7150/jca.28394. eCollection 2019.

DOI:10.7150/jca.28394
PMID:31031845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6485233/
Abstract

The systemic spread of malignant cells from a primary site, a process termed metastasis represents a global challenge in cancer treatment. There is a real need to develop novel therapy strategies and nanomedicine may have remarkable and valuable contribution through specific and selective delivery of chemotherapeutic agents, through its intrinsic cytotoxic activity or through imaging applications, appealing also in the context of cancer personalized therapy. This review is focused on the applications of nanoparticles in the treatment of metastatic cancer, particularly on the possible effect on cell stabilization, growth inhibition, eventual interaction with adhesion molecules and antiangiogenic effect.

摘要

恶性细胞从原发部位发生全身扩散，这一过程称为转移，是癌症治疗中的一个全球性挑战。确实需要开发新的治疗策略，而纳米医学可能通过特异性和选择性递送化疗药物、凭借其内在的细胞毒性活性或通过成像应用做出显著且有价值的贡献，在癌症个性化治疗的背景下也颇具吸引力。本综述聚焦于纳米颗粒在转移性癌症治疗中的应用，尤其关注其对细胞稳定、生长抑制、与黏附分子的最终相互作用以及抗血管生成作用的可能影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b6/6485233/5dd7d980a4e7/jcav10p1358g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b6/6485233/3b78f6cac626/jcav10p1358g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b6/6485233/849db7b1fec2/jcav10p1358g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b6/6485233/5b73ba1061eb/jcav10p1358g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b6/6485233/41bf9115565a/jcav10p1358g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b6/6485233/5dd7d980a4e7/jcav10p1358g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b6/6485233/3b78f6cac626/jcav10p1358g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b6/6485233/849db7b1fec2/jcav10p1358g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b6/6485233/5b73ba1061eb/jcav10p1358g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b6/6485233/41bf9115565a/jcav10p1358g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4b6/6485233/5dd7d980a4e7/jcav10p1358g005.jpg

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Nanotechnology in metastatic cancer treatment: Current Achievements and Future Research Trends.

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[2]
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[3]
Chitosan-Coated-PLGA Nanoparticles Enhance the Antitumor and Antimigration Activity of Stattic - A STAT3 Dimerization Blocker.

Int J Nanomedicine. 2022

[4]
Pulmonary Delivery of Anticancer Drugs via Lipid-Based Nanocarriers for the Treatment of Lung Cancer: An Update.

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[5]
Targeting cancer cell adhesion molecule, CD146, with low-dose gold nanorods and mild hyperthermia disrupts actin cytoskeleton and cancer cell migration.

J Colloid Interface Sci. 2021-11

[6]
Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review.

ACS Pharmacol Transl Sci. 2021-3-3

[7]
Nanotechnology-Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis.

Adv Healthc Mater. 2021-5

[8]
Emerging Prospects for Nanoparticle-Enabled Cancer Immunotherapy.

J Immunol Res. 2020

[9]
Exploiting Current Understanding of Hypoxia Mediated Tumour Progression for Nanotherapeutic Development.

Cancers (Basel). 2019-12-11

本文引用的文献

[1]
Optimization of Transforming Growth Factor-β1 siRNA Loaded Chitosan-Tripolyphosphate Nanoparticles for the Treatment of Colorectal Cancer Hepatic Metastasis in a Mouse Model.

J Biomed Nanotechnol. 2016-7

[2]
JAK/STAT and TGF-ß activation as potential adverse outcome pathway of TiONPs phototoxicity in Caenorhabditis elegans.

Sci Rep. 2017-12-19

[3]
EMT and Treatment Resistance in Pancreatic Cancer.

Cancers (Basel). 2017-9-12

[4]
Silica nanoparticles induce liver fibrosis via TGF-β/Smad3 pathway in ICR mice.

Int J Nanomedicine. 2017-8-21

[5]
Epigenetic Regulation of the Epithelial to Mesenchymal Transition in Lung Cancer.

Cancers (Basel). 2017-6-24

[6]
Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins.

Proc Natl Acad Sci U S A. 2017-6-26

[7]
Carbon nanotubes as anti-bacterial agents.

Cell Mol Life Sci. 2017-10

[8]
Laser thermal ablation of multidrug-resistant bacteria using functionalized gold nanoparticles.

Int J Nanomedicine. 2017-3-23

[9]
Chitosan nanoparticles as a dual drug/siRNA delivery system for treatment of colorectal cancer.

Immunol Lett. 2017-1

[10]
Gold nanoparticle-conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2-mediated pathway in breast cancer.

Cell Prolif. 2016-12

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