Gonciar Diana, Mocan Teodora, Matea Cristian Tudor, Zdrehus Claudiu, Mosteanu Ofelia, Mocan Lucian, Pop Teodora
Third Surgery Clinic, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania.
Nanomedicine Department, Regional Institute of Gastroenterology and Hepatology "Prof.Dr. Octavian Fodor" Cluj-Napoca , Romania.
J Cancer. 2019 Feb 7;10(6):1358-1369. doi: 10.7150/jca.28394. eCollection 2019.
The systemic spread of malignant cells from a primary site, a process termed metastasis represents a global challenge in cancer treatment. There is a real need to develop novel therapy strategies and nanomedicine may have remarkable and valuable contribution through specific and selective delivery of chemotherapeutic agents, through its intrinsic cytotoxic activity or through imaging applications, appealing also in the context of cancer personalized therapy. This review is focused on the applications of nanoparticles in the treatment of metastatic cancer, particularly on the possible effect on cell stabilization, growth inhibition, eventual interaction with adhesion molecules and antiangiogenic effect.
恶性细胞从原发部位发生全身扩散，这一过程称为转移，是癌症治疗中的一个全球性挑战。确实需要开发新的治疗策略，而纳米医学可能通过特异性和选择性递送化疗药物、凭借其内在的细胞毒性活性或通过成像应用做出显著且有价值的贡献，在癌症个性化治疗的背景下也颇具吸引力。本综述聚焦于纳米颗粒在转移性癌症治疗中的应用，尤其关注其对细胞稳定、生长抑制、与黏附分子的最终相互作用以及抗血管生成作用的可能影响。
