Molecular Imaging Program at Stanford, Department of Radiology, Stanford, CA, USA.
Phys Med Biol. 2010 Oct 7;55(19):5895-911. doi: 10.1088/0031-9155/55/19/018. Epub 2010 Sep 16.
Performance of a new high resolution PET detection concept is presented. In this new concept, annihilation radiation enters the scintillator detectors edge-on. Each detector module comprises two 8 × 8 LYSO scintillator arrays of 0.91 × 0.91 × 1 mm(3) crystals coupled to two position-sensitive avalanche photodiodes (PSAPDs) mounted on a flex circuit. Appropriate crystal segmentation allows the recording of all three spatial coordinates of the interaction(s) simultaneously with submillimeter resolution. We report an average energy resolution of 14.6 ± 1.7% for 511 keV photons at FWHM. Coincident time resolution was determined to be 2.98 ± 0.13 ns FWHM on average. The coincidence point spread function (PSF) has an average FWHM of 0.837 ± 0.049 mm (using a 500 μm spherical source) and is uniform across the arrays. Both PSF and coincident time resolution degrade when Compton interactions are included in the data. Different blurring factors were evaluated theoretically, resulting in a calculated PSF of 0.793 mm, in good agreement with the measured value.
呈现了一种新的高分辨率 PET 探测概念的性能。在这个新概念中，湮没辐射以边缘入射的方式进入闪烁体探测器。每个探测器模块由两个 8×8 的 LYSO 闪烁体阵列组成，每个阵列由 0.91×0.91×1mm(3)的晶体组成，并与安装在柔性电路板上的两个位置灵敏雪崩光电二极管 (PSAPD) 耦合。适当的晶体分段允许以亚毫米分辨率同时记录相互作用的所有三个空间坐标。我们报告了在 FWHM 处 511keV 光子的平均能量分辨率为 14.6±1.7%。平均符合时间分辨率为 2.98±0.13ns FWHM。符合点扩散函数 (PSF) 的平均 FWHM 为 0.837±0.049mm（使用 500μm 球形源），并且在整个阵列中是均匀的。当将康普顿相互作用包括在数据中时，PSF 和符合时间分辨率都会降低。理论上评估了不同的模糊因素，导致计算的 PSF 为 0.793mm，与测量值吻合良好。
