Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Internal zip code BB70, PO Box 30001, 9700 RB Groningen, The Netherlands.
Support Care Cancer. 2011 Oct;19(10):1675-83. doi: 10.1007/s00520-010-1001-z. Epub 2010 Sep 16.
This study aimed to assess prevalence of malnutrition after treatment for oral/oropharyngeal cancer and to explore how oral symptoms relate to malnutrition after treatment.
In this cross-sectional study, malnutrition (weight loss ≥ 10% in 6 months or ≥ 5% in 1 month), oral symptoms (EORTC QLQ-H&N35 questionnaire and additional questions to assess chewing problems), dental status, trismus and dietary intake were assessed in 116 adult patients treated for oral/oropharyngeal cancer.
Prevalence of malnutrition was 16% (95%CI: 10% to 23%). Prevalence of malnutrition in the period 0-3 months after treatment was significantly higher (25%) than in the periods >3-12 months (13%) and >12-36 months after treatment (3%, p = 0.008). Logistic multivariate regression analysis revealed that swallowing problems (p = 0.021) and insufficient protein intake were significantly related to malnutrition (p = 0.016).
In conclusion, malnutrition is a considerable problem in patients treated for oral/oropharyngeal cancer, shortly after treatment. Of all oral symptoms, only swallowing problems were significantly related to malnutrition in the period after treatment for oral/oropharyngeal cancer.
本研究旨在评估口腔/口咽癌治疗后营养不良的发生率，并探讨口腔症状与治疗后营养不良的关系。
在这项横断面研究中，评估了 116 名接受口腔/口咽癌治疗的成年患者的营养不良（6 个月内体重减轻≥10%或 1 个月内体重减轻≥5%）、口腔症状（EORTC QLQ-H&N35 问卷和评估咀嚼问题的附加问题）、牙齿状况、张口困难和饮食摄入情况。
营养不良的发生率为 16%（95%CI：10%至 23%）。治疗后 0-3 个月的营养不良发生率（25%）明显高于治疗后 3-12 个月（13%）和 12-36 个月（3%）（p=0.008）。Logistic 多变量回归分析显示，吞咽问题（p=0.021）和蛋白质摄入不足与营养不良显著相关（p=0.016）。
总之，口腔/口咽癌治疗后不久，患者存在相当程度的营养不良问题。在所有口腔症状中，只有吞咽问题与口腔/口咽癌治疗后时期的营养不良显著相关。
