Department of Radiology, Beaumont Hospital, Beaumont Road, PO Box 1297, Dublin 9, Ireland.
Cardiovasc Intervent Radiol. 2011 Aug;34(4):676-90. doi: 10.1007/s00270-010-9967-y. Epub 2010 Sep 16.
Nanotechnology can be defined as the design, creation, and manipulation of structures on the nanometer scale. This two-part review is intended to acquaint the interventionalist with the field of nanotechnology, and provide an overview of potential applications, while highlighting advances relevant to interventional radiology. Part 2 of the article concentrates on drug delivery, thermotherapy, and vascular intervention. In oncology, advances in drug delivery allow for improved efficacy, decreased toxicity, and greater potential for targeted therapy. Magnetic nanoparticles show potential for use in thermotherapy treatments of various tumours, and the effectiveness of radiofrequency ablation can be enhanced with nanoparticle chemotherapy agents. In vascular intervention, much work is focused on prevention of restenosis through developments in stent technology and systems for localised drug delivery to vessel walls. Further areas of interest include applications for thrombolysis and haemostasis.
纳米技术可以被定义为在纳米尺度上设计、创造和操纵结构。这篇由两部分组成的综述旨在让介入放射学家了解纳米技术领域，并概述潜在的应用，同时强调与介入放射学相关的进展。文章的第二部分集中在药物输送、热疗和血管介入。在肿瘤学中，药物输送的进步可以提高疗效、降低毒性，并且更有针对性治疗的潜力。磁性纳米颗粒在各种肿瘤的热疗治疗中显示出应用潜力，并且可以通过纳米粒子化疗药物增强射频消融的效果。在血管介入中，许多工作都集中在通过支架技术和局部药物输送系统的发展来预防再狭窄。进一步的关注领域包括溶栓和止血的应用。
