5,6-二氢-5-氮杂胸苷：针对人类疱疹病毒的体外抗病毒特性

5,6-Dihydro-5-azathymidine: in vitro antiviral properties against human herpesviruses.

作者信息

Renis H E

出版信息

Antimicrob Agents Chemother. 1978 Apr;13(4):613-7. doi: 10.1128/AAC.13.4.613.

DOI:10.1128/AAC.13.4.613

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352297/

Abstract

5,6-Dihydro-5-azathymidine (DHAdT), a novel water-soluble nucleoside antibiotic, inhibits herpes simplex virus type 1 (HSV-1) in appropriately infected cell cultures to a greater extent than herpes simplex virus type 2 (HSV-2). Vaccinia virus was less susceptible than HSV-2, and pseudorabies virus yields were not reduced at the concentrations studied. Plaque formation by varicella-zoster virus was suppressed by DHAdT. DHAdT was slightly toxic to cells at concentrations that were inhibitory for HSV-1 and varicella-zoster virus. Thymidine and deoxyuridine completely reversed the anti-HSV-1 activity of DHAdT, whereas deoxycytidine was partially effective. Compared with other nucleoside analogs with activity for HSV-1, DHAdT was less active than 5-iodo-2'-deoxyuridine or 1-beta-d-arabinofuranosylcytosine and nearly equipotent with 9-beta-d-arabinofuranosyladenine.

摘要

5,6-二氢-5-氮杂胸苷（DHAdT）是一种新型水溶性核苷抗生素，在适当感染的细胞培养物中，它对1型单纯疱疹病毒（HSV-1）的抑制作用比对2型单纯疱疹病毒（HSV-2）的抑制作用更强。痘苗病毒比HSV-2更不易感，在所研究的浓度下，伪狂犬病病毒的产量没有降低。水痘-带状疱疹病毒的空斑形成受到DHAdT的抑制。在对HSV-1和水痘-带状疱疹病毒有抑制作用的浓度下，DHAdT对细胞有轻微毒性。胸苷和脱氧尿苷完全逆转了DHAdT的抗HSV-1活性，而脱氧胞苷部分有效。与其他对HSV-1有活性的核苷类似物相比，DHAdT的活性低于5-碘-2'-脱氧尿苷或1-β-D-阿拉伯呋喃糖基胞嘧啶，与9-β-D-阿拉伯呋喃糖基腺嘌呤几乎等效。

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