双膦酸盐与颌骨骨坏死的关系：Wistar 大鼠的研究。
Association between bisphosphonates and jaw osteonecrosis: a study in Wistar rats.
机构信息
Postgraduate Program of Dental College, PUCRS, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
出版信息
Head Neck. 2011 Feb;33(2):199-207. doi: 10.1002/hed.21422.
BACKGROUND
This work aimed at determining whether bisphosphonate therapy produces a sufficient condition for jaw osteonecrosis after tooth extraction.
METHODS
Rats were allocated into 3 groups: (1) 11 rats treated with alendronate, (2) 10 rats treated with zoledronic acid, and (3) 10 control rats. The animals were subjected to tooth extractions, and at the end of bisphosphonate therapy, they were humanely killed. Histologic sections of the surgical site were processed and analyzed.
RESULTS
The zoledronic acid group showed higher incidences of osteonecrosis, inflammatory infiltrate, and microorganisms. There was no significant difference for epithelial or connective tissue, root fragments, vital bone, and positive staining for vascular endothelial growth factor (VEGF) among the groups.
CONCLUSION
Zoledronic acid is associated with jaw osteonecrosis, whereas alendronate did not produce a condition sufficient for osteonecrosis after tooth extraction. Neither zoledronic acid nor alendronate was associated with a reduced immunohistochemical expression of VEGF in vital bone at the tooth extraction site.
背景
本研究旨在确定双膦酸盐治疗是否为拔牙后颌骨坏死提供充分条件。
方法
将大鼠分为 3 组：（1）11 只接受阿仑膦酸钠治疗，（2）10 只接受唑来膦酸治疗，（3）10 只对照大鼠。对动物进行拔牙，在双膦酸盐治疗结束时，对其进行安乐死。对手术部位的组织学切片进行处理和分析。
结果
唑来膦酸组的坏死、炎症浸润和微生物发生率更高。各组间上皮组织或结缔组织、根碎片、有活力的骨以及血管内皮生长因子（VEGF）的阳性染色均无显著差异。
结论
唑来膦酸与颌骨坏死有关，而阿仑膦酸钠在拔牙后并未产生足以导致坏死的条件。唑来膦酸和阿仑膦酸钠均未导致拔牙部位有活力骨中 VEGF 的免疫组织化学表达减少。
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