Donald Danforth Plant Science Center, St. Louis, MO, USA.
Biofactors. 2010 Sep-Oct;36(5):394-400. doi: 10.1002/biof.126.
Resveratrol, a compound commonly found in red wine, has attracted many attentions recently. It is a diphenolic natural product accumulated in grapes and a few other species under stress conditions. It possesses a special ability to increase the life span of eukaryotic organisms, ranging from yeast, to fruit fly, to obese mouse. The demand for resveratrol as a food and nutrition supplement has increased significantly in recent years. Extensive work has been carried out to increase the production of resveratrol in plants and microbes. In this review, we will discuss the biosynthetic pathway of resveratrol and engineering methods to heterologously express the pathway in various organisms. We will outline the shortcuts and limitations of common engineering efforts. We will also discuss briefly the features and engineering challenges of other longevity boosting compounds.
白藜芦醇是一种常见于红酒中的化合物，最近引起了广泛关注。它是一种二酚类天然产物，在葡萄和其他一些物种受到压力时积累。它具有特殊的能力，可以延长从酵母、果蝇到肥胖老鼠等真核生物的寿命。近年来，人们对作为食品和营养补充剂的白藜芦醇的需求显著增加。人们已经开展了广泛的工作来增加植物和微生物中白藜芦醇的产量。在这篇综述中，我们将讨论白藜芦醇的生物合成途径以及在各种生物体中异源表达该途径的工程方法。我们将概述常见工程努力的捷径和局限性。我们还将简要讨论其他长寿增强化合物的特点和工程挑战。
