Uppsala University.
Brief Bioinform. 2011 Nov;12(6):702-13. doi: 10.1093/bib/bbq064. Epub 2010 Sep 17.
The amount of information regarding protein-protein interactions (PPI) at a proteomic scale is constantly increasing. This is paralleled with an increase of databases making information available. Consequently there are diverse ways of delivering information about not only PPIs but also regarding the databases themselves. This creates a time consuming obstacle for many researchers working in the field. Our survey provides a valuable tool for researchers to reduce the time necessary to gain a broad overview of PPI-databases and is supported by a graphical representation of data exchange. The graphical representation is made available in cooperation with the team maintaining www.pathguide.org and can be accessed at http://www.pathguide.org/interactions.php in a new Cytoscape web implementation. The local copy of Cytoscape cys file can be downloaded from http://bio.icm.edu.pl/~darman/ppi web page.
蛋白质-蛋白质相互作用（PPI）的信息量在蛋白质组学层面上不断增加。这与使信息可用的数据库的增加是并行的。因此，不仅有多种方式提供有关 PPI 的信息，还有关于数据库本身的信息。这给许多在该领域工作的研究人员带来了耗时的障碍。我们的调查为研究人员提供了一个有价值的工具，可减少获得 PPI 数据库广泛概述所需的时间，并且得到了数据交换的图形表示的支持。图形表示可与维护 www.pathguide.org 的团队合作获得，并可在新的 Cytoscape 网络实现中访问 http://www.pathguide.org/interactions.php。Cytoscape cys 文件的本地副本可从 http://bio.icm.edu.pl/~darman/ppi 网页下载。
