人口腔病原菌变形链球菌的突变杆菌素 A 是调控酵母-菌丝过渡的跨领域调控因子。
Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition.
机构信息
Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, OK 73019, USA.
出版信息
Org Biomol Chem. 2010 Dec 21;8(24):5486-9. doi: 10.1039/c0ob00579g. Epub 2010 Sep 20.
Abstract
The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.
摘要
最近对口腔病原体变形链球菌 UA159 中编码杂种 PKS-NRPS 代谢物的基因簇进行了研究，结果表明该天然产物可能在调节一系列应激耐受因子方面发挥重要作用。我们现已对该基因簇产生的主要化合物——变聚糖 A 进行了特征描述，并证实该次级代谢产物还能够影响白色念珠菌的酵母-菌丝过渡。
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