Runyan Christopher M, Taylor Jesse A
Division of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
Facial Plast Surg. 2010 Oct;26(5):385-95. doi: 10.1055/s-0030-1265017. Epub 2010 Sep 17.
Few areas of translational medicine carry as much excitement and hope as stem cell therapies. Because of recent advances in material science and stem cell and developmental biology that help to target molecules and pathways to restore the body's regenerative capacity, the "engineering" of missing tissue is quickly becoming a reality. Classically, tissue engineering has been thought to require external regenerative resources including a scaffold, cells, and growth factors. The allure of providing an exact replica of a missing bone that incorporates to become indistinguishable from self, has the capacity to heal and grow, is resistant to infection, and has minimal morbidity is a "holy grail" to all surgeons who work with bone. This article attempts to shed light on the use of stem cells for craniofacial reconstruction, including important principles learned from other scientific disciplines, relevant animal models for tissue engineering, early clinical reports from our experience and that of others, and future directions.
在转化医学领域，很少有领域能像干细胞疗法那样令人兴奋并充满希望。由于材料科学、干细胞与发育生物学的最新进展有助于靶向分子和通路以恢复身体的再生能力，缺失组织的“工程化”正迅速成为现实。传统上，组织工程被认为需要外部再生资源，包括支架、细胞和生长因子。提供一块与缺失骨骼完全相同的复制品，使其融入身体后与自身组织难以区分，具有愈合和生长能力、抗感染能力且发病率极低，这对所有从事骨骼相关工作的外科医生来说都是一个“圣杯”。本文旨在阐明干细胞在颅面重建中的应用，包括从其他科学学科中学到的重要原理、组织工程相关的动物模型、我们自己及他人的早期临床报告，以及未来的发展方向。
