Datta Pallab, Ozbolat Veli, Ayan Bugra, Dhawan Aman, Ozbolat Ibrahim T
Center for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology Shibpur, Howrah, 711103, West Bengal, India.
Engineering Science and Mechanics Department, Penn State University, University Park, Pennsylvania.
Biotechnol Bioeng. 2017 Nov;114(11):2424-2431. doi: 10.1002/bit.26349. Epub 2017 Aug 29.
Craniofacial (CF) tissue is an architecturally complex tissue consisting of both bone and soft tissues with significant patient specific variations. Conditions of congenital abnormalities, tumor resection surgeries, and traumatic injuries of the CF skeleton can result in major deficits of bone tissue. Despite advances in surgical reconstruction techniques, management of CF osseous deficits remains a challenge. Due its inherent versatility, bioprinting offers a promising solution to address these issues. In this review, we present and analyze the current state of bioprinting of bone tissue and highlight how these techniques may be adapted to serve regenerative therapies for CF applications. Biotechnol. Bioeng. 2017;114: 2424-2431. © 2017 Wiley Periodicals, Inc.
颅面（CF）组织是一种结构复杂的组织，由骨骼和软组织组成，具有显著的患者个体差异。先天性异常、肿瘤切除手术以及CF骨骼的创伤性损伤等情况可导致骨组织的重大缺损。尽管手术重建技术取得了进展，但CF骨缺损的管理仍然是一项挑战。由于其固有的多功能性，生物打印为解决这些问题提供了一个有前景的解决方案。在本综述中，我们展示并分析了骨组织生物打印的当前状态，并强调了如何调整这些技术以服务于CF应用的再生治疗。《生物技术与生物工程》2017年；114：2424 - 2431。© 2017威利期刊公司
