Yuan Jie, Cao Yilin, Liu Wei
Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Tissue Engineering Key Laboratory, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Craniofac Surg. 2012 Jan;23(1):294-7. doi: 10.1097/SCS.0b013e318241bae1.
With the advancement in stem cell research and material science, tissue regeneration has been evolved from scientific hypothesis to clinical reality and thus will have a great potential in regenerating craniofacial tissue. In this approach, scaffold plays an essential role in tissue regeneration by recruiting host regenerative cells or enhancing adhesion, proliferation and matrix production of seeded cells, and eventual formation of the desired tissue type. Moreover, incorporation of biomimesis concept into scaffold design and manufacture will further enhance the quality and function of regenerated tissues. This article summarizes new developments of biomimetic scaffolds including the biomimesis of extracellular matrix, cell-matrix interaction, and tissue-regenerative signaling.
随着干细胞研究和材料科学的进步，组织再生已从科学假设发展为临床现实，因此在颅面组织再生方面具有巨大潜力。在这种方法中，支架通过募集宿主再生细胞或增强接种细胞的黏附、增殖和基质产生，以及最终形成所需的组织类型，在组织再生中起着至关重要的作用。此外，将仿生概念融入支架设计和制造中将进一步提高再生组织的质量和功能。本文总结了仿生支架的新进展，包括细胞外基质的仿生、细胞 - 基质相互作用和组织再生信号。
