Department of Histology, Stem Cells Laboratory, University School of Medicine, Nis, Serbia.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Sep;114(3):e1-9. doi: 10.1016/j.oooo.2012.02.030.
There are numerous conditions, such as trauma, cancer, congenital malformations, and progressive deforming skeletal diseases, that can compromise the function and architectonics of bones of craniofacial region. The need to develop new approaches for treatment of these disorders arises from the fact that conventional therapeutic strategies face many obstacles and limitations. The use of tissue engineering in regeneration of craniofacial bone structures is a very promising possibility and a great challenge for researchers and practitioners. Developments in stem cell biology and engineering have led to the discovery of different stem cell populations and biodegradable materials with suitable properties. This review summarizes the current achievements in tissue engineering of craniofacial bone, temporomandibular joint, and periodontal ligament.
有许多病症，如创伤、癌症、先天畸形和进行性骨骼变形疾病等，都会影响颅面区域骨骼的功能和结构。由于传统的治疗策略面临许多障碍和限制，因此需要开发新的治疗方法来治疗这些疾病。组织工程在颅面骨结构再生中的应用是一个非常有前途的可能性，也是研究人员和从业者的巨大挑战。干细胞生物学和工程学的发展导致了不同的干细胞群体和具有合适性能的可生物降解材料的发现。这篇综述总结了颅面骨、颞下颌关节和牙周韧带组织工程的最新成果。
