Mukai Rie, Nakao Reiko, Yamamoto Hironori, Nikawa Takeshi, Takeda Eiji, Terao Junji
Department of Food Science, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770-8503, Japan.
J Nat Prod. 2010 Oct 22;73(10):1708-10. doi: 10.1021/np100240y. Epub 2010 Sep 20.
The effects of quercetin (1) were investigated on disused muscle atrophy using mice that underwent tail suspension. Periodic injection of 1 into the gastrocnemius muscle suppressed muscle weight loss and ubiquitin ligase expression. Compound 1 reduced the enhancement of lipid peroxidation in the muscle. Injection of N-acetyl-l-cysteine, but not flavone (2), also prevented muscle weight loss and enhancement of lipid peroxidation. These findings demonstrate that 1 can prevent disused muscle atrophy by attenuating the expression of ubiquitin ligases and that such prevention originates from its antioxidant activity.
使用尾部悬吊的小鼠研究了槲皮素（1）对废用性肌肉萎缩的影响。向腓肠肌定期注射1可抑制肌肉重量减轻和泛素连接酶表达。化合物1减少了肌肉中脂质过氧化的增强。注射N-乙酰半胱氨酸而非黄酮（2）也可防止肌肉重量减轻和脂质过氧化增强。这些发现表明，1可通过减弱泛素连接酶的表达来预防废用性肌肉萎缩，且这种预防源于其抗氧化活性。
