Communicable Diseases Centre, National Institute of Public Health of Slovenia, Trubarjeva 2, 1000 Ljubljana, Slovenia.
Vaccine. 2010 Oct 28;28(46):7396-400. doi: 10.1016/j.vaccine.2010.09.003. Epub 2010 Sep 20.
The aim of the paper is to present the results of the investigation of a series of four cases of tick-borne encephalitis (TBE) reported from Gorenjska region in Slovenia in 2008 despite vaccination against TBE, propose surveillance case definition for TBE and classification criteria for TBE vaccine failure cases, to discuss challenges in the interpretation of TBE serology results in previously vaccinated patients and propose ascertainment procedures for vaccine failure cases. Establishing surveillance of vaccine failure cases on national and European level is essential for monitoring and evaluating the impact of immunization, evaluation of vaccine effectiveness and early warning for the need to change the vaccination schedule recommendations.
本文旨在介绍 2008 年斯洛文尼亚戈里纳地区报告的四例蜱传脑炎（TBE）病例的调查结果，提出 TBE 监测病例定义和 TBE 疫苗失败病例分类标准，讨论在既往接种疫苗患者中 TBE 血清学结果解释的挑战，并提出疫苗失败病例的确定程序。在国家和欧洲层面建立疫苗失败病例监测对于监测和评估免疫接种的影响、评估疫苗效力以及早期预警需要改变疫苗接种时间表建议至关重要。
