Feige Julia, Moser Tobias, Hauer Larissa, Pikija Slaven, Sellner Johann
Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria.
Vaccines (Basel). 2020 Feb 20;8(1):93. doi: 10.3390/vaccines8010093.
Vaccination is an effective means to prevent infectious diseases including tick-borne encephalitis (TBE), an emerging Flavivirus infection. There is, however, only limited knowledge about risk of vaccination failure, the disease course and the challenges for work-up and care. Of note, there is evidence that patients with breakthrough disease experience a more severe disease course. We report the case of a previously healthy 49-year-old woman who developed severe myeloradiculitis caused by the TBE virus despite receiving a complete cycle of primary immunization and booster vaccinations within the recommended timeframe. The disease course was characterized by progressive tetraparesis, pain and bladder dysfunction and necessitated intensive care unit admission (ICU) and the escalation of pain management. This case raises awareness for the recognition of breakthrough disease in younger patients and reinforces the need to develop measures to identify patients with insufficient protection.
接种疫苗是预防包括蜱传脑炎（TBE）在内的传染病的有效手段，蜱传脑炎是一种新出现的黄病毒感染。然而，关于疫苗接种失败的风险、疾病进程以及检查和护理方面的挑战，人们了解有限。值得注意的是，有证据表明突破性疾病患者的病程更为严重。我们报告了一例先前健康的49岁女性病例，尽管在推荐时间范围内接受了完整的初次免疫和加强疫苗接种，但仍感染了由蜱传脑炎病毒引起的严重脊髓神经根炎。病程的特点是进行性四肢轻瘫、疼痛和膀胱功能障碍，需要入住重症监护病房（ICU）并加强疼痛管理。该病例提高了对年轻患者突破性疾病识别的认识，并强化了制定措施以识别保护不足患者的必要性。
