Orcurto Angela, Gay Béatrice E, Sozzi Wendy Jeanneret, Gilliet Michel, Leyvraz Serge
Multidisciplinary Oncology Center, University Hospital, Lausanne, Switzerland.
Radiation Oncology Service, University Hospital, Lausanne, Switzerland.
Case Rep Dermatol. 2014 Mar 13;6(1):80-4. doi: 10.1159/000360806. eCollection 2014 Jan.
Sebaceous carcinoma (SC) is an uncommon neoplasm manifesting itself either in the eyelid or extraocularly in the head and neck area. Surgery is the standard of care. Irradiation is rarely proposed as monotherapy but is frequently administered as an adjuvant regimen following surgical resection. There is no known strategy concerning chemotherapeutic treatment in highly aggressive recurrent - or metastatic - forms of the disease. Our patient presented with an aggressive SC of the scalp recurring after multiple excisions and local radiotherapy. Chemotherapy with 5-fluorouracil, cisplatin and docetaxel was then initiated; 4 cycles were administered, followed by capecitabine maintenance. Shortly after starting chemotherapy, dermal lesions had completely disappeared and radiological response could be seen. The patient experienced an extended period (>20 months) of complete remission. In this report, we show an excellent response of a highly aggressive SC after a combination of chemotherapy as for head and neck cancers.
皮脂腺癌（SC）是一种罕见的肿瘤，可发生于眼睑或头颈部的眼外部位。手术是标准的治疗方法。放疗很少作为单一疗法使用，但常在手术切除后作为辅助治疗方案应用。对于该疾病高度侵袭性的复发或转移形式，尚无已知的化疗策略。我们的患者表现为头皮部侵袭性皮脂腺癌，在多次切除和局部放疗后复发。随后开始使用5-氟尿嘧啶、顺铂和多西他赛进行化疗；共进行了4个周期，之后用卡培他滨维持治疗。开始化疗后不久，皮肤病变完全消失，可见放射学反应。患者经历了超过20个月的完全缓解期。在本报告中，我们展示了一种针对头颈部癌的联合化疗方案对高度侵袭性皮脂腺癌产生的极佳疗效。
