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特发性震颤概述。

Overview of essential tremor.

机构信息

Department of Neurology, Parkinson Research Foundation, James A. Haley Veterans Administration Hospital, University of South Florida, Tampa, FL, USA.

出版信息

Neuropsychiatr Dis Treat. 2010 Sep 7;6:401-8. doi: 10.2147/ndt.s4795.

DOI:10.2147/ndt.s4795
PMID:20856604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2938289/
Abstract

Essential tremor (ET) is one of the most common movement disorders in the world. Despite this, only one medication (propranolol) is approved by the Food and Drug Administration (FDA) to treat it. Fortunately, recent studies have identified some additional medications as treatment of ET. Surgical procedures, such as deep brain stimulation of the ventral intermediate nucleus of the thalamus, offer treatment for refractory tremor. The epidemiology, pathogenesis, and medical and surgical treatment of ET will be discussed in this paper.

摘要

特发性震颤(ET)是世界上最常见的运动障碍之一。尽管如此,只有一种药物(普萘洛尔)被美国食品和药物管理局(FDA)批准用于治疗该病。幸运的是,最近的研究已经确定了一些其他药物可用于治疗 ET。手术程序,如丘脑腹侧中间核的深部脑刺激,为难治性震颤提供了治疗方法。本文将讨论 ET 的流行病学、发病机制以及医学和手术治疗。

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本文引用的文献

1
Functional correlates of lower cognitive test scores in essential tremor.特发性震颤患者认知测验分数较低的功能相关性。
Mov Disord. 2010 Mar 15;25(4):481-5. doi: 10.1002/mds.22920.
2
Essential tremor--neurodegenerative or nondegenerative disease towards a working definition of ET.特发性震颤——神经退行性或非神经退行性疾病,向特发性震颤的工作定义迈进。
Mov Disord. 2009 Oct 30;24(14):2033-41. doi: 10.1002/mds.22755.
3
Efficacy and tolerability of pregabalin in essential tremor: a randomized, double-blind, placebo-controlled, crossover trial.普瑞巴林治疗特发性震颤的疗效和耐受性:一项随机、双盲、安慰剂对照、交叉试验。
J Neurol Sci. 2009 Oct 15;285(1-2):195-7. doi: 10.1016/j.jns.2009.06.044. Epub 2009 Jul 25.
4
Torpedoes in Parkinson's disease, Alzheimer's disease, essential tremor, and control brains.帕金森病、阿尔茨海默病、特发性震颤和对照脑的神经毒素。
Mov Disord. 2009 Aug 15;24(11):1600-5. doi: 10.1002/mds.22567.
5
Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study.特发性震颤中帕金森病和帕金森综合征的发病风险:一项基于人群的研究。
J Neurol Neurosurg Psychiatry. 2009 Apr;80(4):423-5. doi: 10.1136/jnnp.2008.147223.
6
Hypothetical membrane mechanisms in essential tremor.特发性震颤的假设性膜机制。
J Transl Med. 2008 Nov 6;6:68. doi: 10.1186/1479-5876-6-68.
7
Emergence of Parkinson's disease in essential tremor: a study of the clinical correlates in 53 patients.原发性震颤患者中帕金森病的出现:53例患者的临床相关性研究
Mov Disord. 2008 Aug 15;23(11):1602-5. doi: 10.1002/mds.22161.
8
Topiramate in essential tremor: findings from double-blind, placebo-controlled, crossover trials.托吡酯治疗特发性震颤:双盲、安慰剂对照、交叉试验的结果
Clin Neuropharmacol. 2008 Mar-Apr;31(2):97-103. doi: 10.1097/WNF.0b013e3180d09969.
9
A population-based study of mortality in essential tremor.一项基于人群的特发性震颤死亡率研究。
Neurology. 2007 Nov 20;69(21):1982-9. doi: 10.1212/01.wnl.0000279339.87987.d7.
10
Neuropathological changes in essential tremor: 33 cases compared with 21 controls.特发性震颤的神经病理学改变:33例病例与21例对照的比较。
Brain. 2007 Dec;130(Pt 12):3297-307. doi: 10.1093/brain/awm266. Epub 2007 Nov 19.