Department of Dermatology, School of Medicine, Pusan National University, Seo-gu, Busan, Korea.
J Dermatol. 2010 Oct;37(10):894-9. doi: 10.1111/j.1346-8138.2010.00871.x.
Guttate psoriasis, known to have a better prognosis than other types of psoriasis, shows rapid involution and longer remission, but its clinical course has barely been studied. The aim of this study was to determine the clinical course and to compare the clinical and laboratory features of guttate psoriasis. This is a retrospective study of 26 patients with guttate psoriasis. The patients were divided into two groups; the good one with complete remission and long remission for at least 1 year (group A) and the poor one with incomplete remission and progression into chronic plaque psoriasis (group B). Among 36 patients, 22 patients (61.1%) were group A and 14 patients (38.9%) were group B. In group A, most of the skin lesions disappeared within 8 months. In group B, two patients without proper treatment progressed to plaque psoriasis. The onset age was younger and more frequent upper respiratory infection and high anti-streptolysin O (ASO) titer were found in group A, but family history of psoriasis was more common in group B. Patients had two distingushable clinical courses: rapid involuting course with long-term remission and chronic course without remission. There was a tendency toward younger age of onset with elevated ASO titer in patients with rapid involuting course.
点滴状银屑病的预后要好于其他类型的银屑病，表现为迅速消退和较长的缓解期，但对其临床病程的研究甚少。本研究旨在确定其临床病程，并比较点滴状银屑病的临床和实验室特征。这是一项回顾性研究，共纳入 26 例点滴状银屑病患者。患者分为两组：完全缓解且缓解期至少 1 年的良好组（A 组）和部分缓解、进展为慢性斑块状银屑病的不良组（B 组）。36 例患者中，22 例（61.1%）为 A 组，14 例（38.9%）为 B 组。在 A 组中，大多数皮损在 8 个月内消失。在 B 组中，两名未接受适当治疗的患者进展为斑块状银屑病。A 组患者发病年龄较小，上呼吸道感染更为频繁，抗链球菌溶血素 O（ASO）滴度较高，但 B 组患者的银屑病家族史更为常见。患者有两种截然不同的临床病程：迅速消退伴长期缓解和无缓解的慢性病程。在迅速消退的患者中，发病年龄较轻且 ASO 滴度升高。
