Laboratory of Microbiology and Biomaterials, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Planta Med. 2011 Mar;77(4):401-4. doi: 10.1055/s-0030-1250354. Epub 2010 Sep 22.
This study evaluated the susceptibility of oral pathogenic microorganisms Candida albicans, Streptococcus mutans, Staphylococcus aureus, and Aggregatibacter actinomycetemcomitans to Brazilian medicinal plant extracts of Schinus terebinthifolius (aroeira), Croton campestris (velame), Lafoensia pacari (pacari), Centaurium erythraea (centáurea), Stryphnodendron adstringens (barbatimão), and Anacardium humile (cajuzinho-docerrado), as compared to standardized antimicrobial agents (nystatin, chloramphenicol and tetracycline hydrochloride). Ethanol, hexane and butane fractions from stem barks, rinds, leaves, and/or roots were extracted and tested. Antimicrobial diffusion agar test and MIC were performed according to CLSI. After 24 h of incubation at 37 °C, the diameter of inhibition zones and spectrophotometer readings were measured and compared. The results were reported as means ± standard deviation (M ± SD). With the exception of five extracts that showed no antimicrobial activity, all the extracts tested showed antimicrobial activity, in different levels. This study suggests that extracts from the plants tested could be an alternative therapeutic option for infectious conditions of the oral cavity, such as denture stomatitis, dental caries, and periodontitis.
本研究评估了巴西药用植物 Schinus terebinthifolius（番樱桃）、Croton campestris（velame）、Lafoensia pacari（pacari）、Centaurium erythraea（centáurea）、Stryphnodendron adstringens（barbatimão）和 Anacardium humile（cajuzinho-docerrado）的提取物对口腔病原菌白色念珠菌、变形链球菌、金黄色葡萄球菌和伴放线放线杆菌的敏感性，与标准抗菌剂（制霉菌素、氯霉素和盐酸四环素）进行比较。从茎皮、果皮、叶和/或根中提取并测试了乙醇、己烷和丁烷馏分。根据 CLSI 进行了抗菌扩散琼脂试验和 MIC。在 37°C 孵育 24 小时后，测量并比较了抑制区的直径和分光光度计读数。结果以平均值 ±标准偏差（M ± SD）表示。除了五种没有抗菌活性的提取物外，所有测试的提取物都表现出不同程度的抗菌活性。本研究表明，测试植物的提取物可能是治疗口腔感染性疾病（如义齿性口炎、龋齿和牙周炎）的一种替代治疗选择。
