National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, UK.
Biochem Soc Trans. 2010 Oct;38(5):1329-32. doi: 10.1042/BST0381329.
The glycans (carbohydrates) form a diverse group of biomolecules which play active parts in most physiological processes. The field of structural glycobiology concerns the structures of the glycans themselves, the proteins which interact with them and the nature of the interactions between the two. The resulting information is important for our understanding of human health and disease, and for development of new therapeutic strategies. A series of articles is introduced based on the topics covered at the Structural Glycobiology and Human Health Biochemical Society Focused Meeting. Their subjects range from in-depth determinations of three-dimensional protein structure to broad screening techniques for glycan-protein interactions relevant to disease processes, including bacterial, parasitic and viral infections, inflammatory processes, cancer and diabetes.
糖链(碳水化合物)是一组多样化的生物分子,它们在大多数生理过程中发挥着积极的作用。结构糖生物学领域涉及糖链本身的结构、与它们相互作用的蛋白质以及两者之间相互作用的性质。由此产生的信息对于我们理解人类健康和疾病以及开发新的治疗策略非常重要。一系列文章是基于在结构糖生物学和人类健康生物化学学会专题会议上涵盖的主题介绍的。它们的主题范围从深入确定三维蛋白质结构到广泛筛选与疾病过程相关的糖蛋白相互作用的筛选技术,包括细菌、寄生虫和病毒感染、炎症过程、癌症和糖尿病。